Neuroimaging and connectomics of drug‐resistant epilepsy at multiple scales: From focal lesions to macroscale networks

S Tavakol, J Royer, AJ Lowe, L Bonilha, JI Tracy… - …, 2019 - Wiley Online Library
Epilepsy is among the most common chronic neurologic disorders, with 30%‐40% of
patients having seizures despite antiepileptic drug treatment. The advent of brain imaging …

The piriform, perirhinal, and entorhinal cortex in seizure generation

MS Vismer, PA Forcelli, MD Skopin, K Gale… - Frontiers in neural …, 2015 - frontiersin.org
Understanding neural network behavior is essential to shed light on epileptogenesis and
seizure propagation. The interconnectivity and plasticity of mammalian limbic and …

Dynamic directed interictal connectivity in left and right temporal lobe epilepsy

A Coito, G Plomp, M Genetti, E Abela, R Wiest… - …, 2015 - Wiley Online Library
Objective There is increasing evidence that epileptic activity involves widespread brain
networks rather than single sources and that these networks contribute to interictal brain …

The ENIGMA‐Epilepsy working group: Mapping disease from large data sets

SM Sisodiya, CD Whelan, SN Hatton… - Human brain …, 2022 - Wiley Online Library
Epilepsy is a common and serious neurological disorder, with many different constituent
conditions characterized by their electro clinical, imaging, and genetic features. MRI has …

Large‐scale brain networks are distinctly affected in right and left mesial temporal lobe epilepsy

BM de Campos, AC Coan, C Lin Yasuda… - Human brain …, 2016 - Wiley Online Library
Mesial temporal lobe epilepsy (MTLE) with hippocampus sclerosis (HS) is associated with
functional and structural alterations extending beyond the temporal regions and abnormal …

Differences in functional connectivity profiles as a predictor of response to anterior thalamic nucleus deep brain stimulation for epilepsy: a hypothesis for the …

EH Middlebrooks, SS Grewal, M Stead… - Neurosurgical …, 2018 - thejns.org
OBJECTIVE Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is a
promising therapy for refractory epilepsy. Unfortunately, the variability in outcomes from ANT …

Mechanisms of cognitive impairment in temporal lobe epilepsy: a systematic review of resting-state functional connectivity studies

V Ives-Deliperi, JT Butler - Epilepsy & Behavior, 2021 - Elsevier
Temporal lobe epilepsy is the most common form of focal epilepsy and related cognitive
dysfunction impacts significantly on quality of life in patients. Identifying the mechanisms of …

Social cognition in temporal lobe epilepsy: a systematic review and meta-analysis

E Bora, S Meletti - Epilepsy & Behavior, 2016 - Elsevier
Objective There is increasing evidence suggesting that social cognitive abilities are
impaired in temporal lobe epilepsy (TLE), the most common form of focal epilepsies …

The Relationship between Glucose Metabolism, Resting-State fMRI BOLD Signal, and GABAA-Binding Potential: A Preliminary Study in Healthy Subjects and Those …

AC Nugent, A Martinez, A D'alfonso… - Journal of Cerebral …, 2015 - journals.sagepub.com
Glucose metabolism has been associated with magnitude of blood oxygen level-dependent
(BOLD) signal and connectivity across subjects within the default mode and dorsal attention …

The roles of surgery and technology in understanding focal epilepsy and its comorbidities

DD Spencer, JL Gerrard, HP Zaveri - The Lancet Neurology, 2018 - thelancet.com
Intracranial electrophysiological recording in patients with refractory focal epilepsy is the
gold standard for defining epileptogenic tissue. Although the concordance of intracranial …