Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

The desire and need to minimize traditional open surgeries is gearing up as it could reduce
the healthcare expenses and improve the recovery time for the patients. Minimal invasive …

Unlike natural macromolecules (eg, nucleic acids and proteins) possessing precisely
defined molar mass, chain sequence, chirality, and topology, synthetic polymers are typically …

The Huisgen 1, 3-dipolar cycloaddition reaction of organic azides and alkynes1, 2 has
gained considerable attention in recent years due to the introduction in 2001 of Cu (1) …

Natural macromolecules, such as proteins and nucleic acids, display various complex
functionalities in biological systems. These functionalities depend on the macromolecular …

Transition metal catalyzed denitrogenative transannulation of a triazole ring has recently
received considerable attention as a new concept for the construction of diverse nitrogen …

In recent years, there has been an ever‐increasing need for rapid reactions that meet the
three main criteria of an ideal synthesis: efficiency, versatility, and selectivity. Such reactions …

This critical review concerns the impact of copper-mediated alkyne–azide cycloadditions on
peptidomimetic studies. It discusses how this reaction has been used to insert triazoles into …

Over the past decade, protein–protein interactions (PPIs) have gone from being neglected
as 'undruggable'to being considered attractive targets for the development of therapeutics …

The CuAAC “click” reaction has developed as one of the most useful and widely employed
reactions in ligation within polymer chemistry. This is due to the unique properties of the Cu …