The cell cycle is the series of events that take place in a cell, which drives it to divide and
produce two new daughter cells. The typical cell cycle in eukaryotes is composed of the …

Phosphatase and Tensin Homolog deleted on Chromosome 10 (PTEN) is a dual
phosphatase with both protein and lipid phosphatase activities. PTEN was first discovered …

Among the long list of age-related complications, Alzheimer's disease (AD) has the most
dreadful impact on the quality of life due to its devastating effects on memory and cognitive …

Cancer incidences are growing and cause millions of deaths worldwide. Cancer therapy is
one of the most important challenges in medicine. Improving therapeutic outcomes from …

Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a well-
characterized tumour-suppressor gene that is lost or mutated in about half of metastatic …

INTRODUCTION Inhibition of oncogenic proteins represents a mainstay approach for cancer
therapeutic development. By contrast, pharmacological modulation of tumor suppressor …

The importance of the physiological function of phosphatase and tensin homologue (PTEN)
is illustrated by its frequent disruption in cancer. By suppressing the phosphoinositide 3 …

Regulation of the PI-3 kinase (PI3K)/Akt signalling pathway is essential for maintaining the
integrity of fundamental cellular processes, cell growth, survival, death and metabolism, and …

Elevated rates of reactive oxygen species (ROS) have been detected in almost all cancers,
where they promote many aspects of tumour development and progression. However …

Autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders that include
a variety of forms and clinical phenotypes. This heterogeneity complicates the clinical and …