The mathematics of cancer: integrating quantitative models

PM Altrock, LL Liu, F Michor - Nature Reviews Cancer, 2015 - nature.com
Mathematical modelling approaches have become increasingly abundant in cancer
research. The complexity of cancer is well suited to quantitative approaches as it provides …

Interactions between the immune system and cancer: a brief review of non-spatial mathematical models

R Eftimie, JL Bramson, DJD Earn - Bulletin of mathematical biology, 2011 - Springer
We briefly review spatially homogeneous mechanistic mathematical models describing the
interactions between a malignant tumor and the immune system. We begin with the simplest …

A chaos study of tumor and effector cells in fractional tumor-immune model for cancer treatment

S Kumar, A Kumar, B Samet, JF Gómez-Aguilar… - Chaos, Solitons & …, 2020 - Elsevier
A tumor is most dangerous disease of medical science which is a mass or lumps of tissue
that's formed by an accumulation of abnormal cells. A famous fractional tumor-immune …

Nonlinear modelling of cancer: bridging the gap between cells and tumours

JS Lowengrub, HB Frieboes, F Jin, YL Chuang, X Li… - …, 2009 - iopscience.iop.org
Despite major scientific, medical and technological advances over the last few decades, a
cure for cancer remains elusive. The disease initiation is complex, and including initiation …

A validated mathematical model of cell-mediated immune response to tumor growth

LG de Pillis, AE Radunskaya, CL Wiseman - Cancer research, 2005 - AACR
Mathematical models of tumor-immune interactions provide an analytic framework in which
to address specific questions about tumor-immune dynamics. We present a new …

Mixed immunotherapy and chemotherapy of tumors: modeling, applications and biological interpretations

LG de Pillis, W Gu, AE Radunskaya - Journal of theoretical biology, 2006 - Elsevier
We develop and analyze a mathematical model, in the form of a system of ordinary
differential equations (ODEs), governing cancer growth on a cell population level with …

Mathematical models of avascular tumor growth

T Roose, SJ Chapman, PK Maini - SIAM review, 2007 - SIAM
This review will outline a number of illustrative mathematical models describing the growth
of avascular tumors. The aim of the review is to provide a relatively comprehensive list of …

Predictive pharmacokinetic-pharmacodynamic modeling of tumor growth kinetics in xenograft models after administration of anticancer agents

M Simeoni, P Magni, C Cammia, G De Nicolao, V Croci… - Cancer research, 2004 - AACR
The available mathematical models describing tumor growth and the effect of anticancer
treatments on tumors in animals are of limited use within the drug industry. A simple and …

The dynamics of an optimally controlled tumor model: A case study

LG De Pillis, A Radunskaya - Mathematical and computer modelling, 2003 - Elsevier
We present a phase-space analysis of a mathematical model of tumor growth with an
immune response and chemotherapy. We prove that all orbits are bounded and must …

[图书][B] Multiscale modeling of cancer: an integrated experimental and mathematical modeling approach

V Cristini, J Lowengrub - 2010 - books.google.com
Mathematical modeling, analysis and simulation are set to play crucial roles in explaining
tumor behavior, and the uncontrolled growth of cancer cells over multiple time and spatial …