Mouse models have been instrumental in understanding human disease biology and
proposing possible new treatments. The precise control of the environment and genetic …

The dysregulation of energy homeostasis in obesity involves multihormone resistance.
Although leptin and insulin resistance have been well characterized, catecholamine …

The molecular bases of how host genetic variation impacts the gut microbiome remain
largely unknown. Here we used a genetically diverse mouse population and applied …

Cardiometabolic diseases encompass a range of interrelated conditions that arise from
underlying metabolic perturbations precipitated by genetic, environmental, and lifestyle …

Targeted proteomics enables hypothesis-driven research by measuring the cellular
expression of protein cohorts related by function, disease, or class after perturbation. Here …

The outcome of an encounter with Mycobacterium tuberculosis (Mtb) depends on the
pathogen's ability to adapt to the variable immune pressures exerted by the host …

The microbial communities that inhabit the distal gut of humans and other mammals exhibit
large inter-individual variation. While host genetics is a known factor that influences gut …

A vexing observation in genome-wide association studies (GWASs) is that parallel analyses
in different species may not identify orthologous genes. Here, we demonstrate that cross …

Despite the crucial roles of lipids in metabolism, we are still at the early stages of
comprehensively annotating lipid species and their genetic basis. Mass spectrometry–based …

Genetic susceptibility to type 2 diabetes is primarily due to β cell dysfunction. However, a
genetic study to directly interrogate β cell function ex vivo has never been previously …