Bone fragility in diabetes: novel concepts and clinical implications

LC Hofbauer, B Busse, R Eastell, S Ferrari… - The Lancet Diabetes & …, 2022 - thelancet.com
Increased fracture risk represents an emerging and severe complication of diabetes. The
resulting prolonged immobility and hospitalisations can lead to substantial morbidity and …

Mechanisms of diabetes mellitus-induced bone fragility

N Napoli, M Chandran, DD Pierroz… - Nature Reviews …, 2017 - nature.com
The risk of fragility fractures is increased in patients with either type 1 diabetes mellitus
(T1DM) or type 2 diabetes mellitus (T2DM). Although BMD is decreased in T1DM, BMD in …

Treatment of diabetes in older adults: an Endocrine Society clinical practice guideline

D LeRoith, GJ Biessels, SS Braithwaite… - The Journal of …, 2019 - academic.oup.com
Objective The objective is to formulate clinical practice guidelines for the treatment of
diabetes in older adults. Conclusions Diabetes, particularly type 2, is becoming more …

Systemic complications of acromegaly and the impact of the current treatment landscape: an update

MR Gadelha, L Kasuki, DST Lim… - Endocrine reviews, 2019 - academic.oup.com
Acromegaly is a chronic systemic disease with many complications and is associated with
increased mortality when not adequately treated. Substantial advances in acromegaly …

Diabetes and its effect on bone and fracture healing

H Jiao, E Xiao, DT Graves - Current osteoporosis reports, 2015 - Springer
Diabetes mellitus is a metabolic disorder that increases fracture risk, interferes with bone
formation, and impairs fracture healing. Type 1 diabetes mellitus (T1DM) and type 2 …

Management of endocrine disease: secondary osteoporosis: pathophysiology and management

F Mirza, E Canalis - European journal of endocrinology, 2015 - academic.oup.com
Osteoporosis is a skeletal disorder characterized by decreased mass and compromised
bone strength predisposing to an increased risk of fractures. Although idiopathic …

Impact of diabetes mellitus on bone health

CE Murray, CM Coleman - International journal of molecular sciences, 2019 - mdpi.com
Long-term exposure to a diabetic environment leads to changes in bone metabolism and
impaired bone micro-architecture through a variety of mechanisms on molecular and …

The risk of hip and non-vertebral fractures in type 1 and type 2 diabetes: a systematic review and meta-analysis update

T Vilaca, M Schini, S Harnan, A Sutton, E Poku, IE Allen… - Bone, 2020 - Elsevier
Background Diabetes is associated with increased fracture risk but we do not know what
affects this risk. We investigated the risk of hip and non-vertebral fractures in diabetes and …

Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition

K Fulzele, RC Riddle, DJ DiGirolamo, X Cao, C Wan… - Cell, 2010 - cell.com
Global energy balance in mammals is controlled by the actions of circulating hormones that
coordinate fuel production and utilization in metabolically active tissues. Bone-derived …

Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture

M Janghorbani, RM Van Dam… - American journal of …, 2007 - academic.oup.com
The authors conducted a systematic review of published data on the association between
diabetes mellitus and fracture. The authors searched MEDLINE through June 2006 and …