Efforts to develop neuroprotective therapy for Parkinson disease (PD) are focusing on the
early stages of disease, which offer the best opportunity to intervene. Early PD can be …

Restless legs syndrome, also known as Willis-Ekbom disease, is a common neurological
condition whose manifestation is affected by complex environmental and genetic …

Sleep disorders are among the most common non-motor manifestations in Parkinson's
disease (PD) and have a significant negative impact on quality of life. While sleep disorders …

Importance The prodromal phase of Parkinson disease (PD) may last for more than 10
years. Recognition of the spectrum and occurrence of risk factors, comorbidities, and …

Importance Disruption in circadian activity rhythms is very common in older adults,
particularly among those with neurodegenerative diseases, including Parkinson disease …

Parkinson's disease (PD) is an alpha-synucleinopathy that leads to prominent motor
symptoms including tremor, bradykinesia, and postural instability. Nonmotor symptoms …

Sleep disturbances may signal presence of prodromal parkinsonism, including Parkinson's
disease. Whether general sleep quality or duration in otherwise healthy subjects is related to …

It is now accepted that disorders of sleep are an integral part of neurodegenerative diseases
but for many years they were not considered a relevant part of these diseases. Many …

Sleep quality and architecture as well as sleep's homeostatic and circadian controls change
with healthy aging. Changes include reductions in slow-wave sleep's (SWS) percent and …

Sleep and circadian alterations are amongst the very first symptoms experienced in
Parkinson's disease, and sleep alterations are present in the majority of patients with overt …