Heavy metals and human health: mechanistic insight into toxicity and counter defense system of antioxidants

AT Jan, M Azam, K Siddiqui, A Ali, I Choi… - International journal of …, 2015 - mdpi.com
Heavy metals, which have widespread environmental distribution and originate from natural
and anthropogenic sources, are common environmental pollutants. In recent decades, their …

Insight into the oxidative stress induced by lead and/or cadmium in blood, liver and kidneys

V Matović, A Buha, D Ðukić-Ćosić, Z Bulat - Food and Chemical Toxicology, 2015 - Elsevier
Besides being important occupational hazards, lead and cadmium are nowadays metals of
great environmental concern. Both metals, without any physiological functions, can induce …

Toxic effect of acute cadmium and lead exposure in rat blood, liver, and kidney

M Andjelkovic, A Buha Djordjevic, E Antonijevic… - International journal of …, 2019 - mdpi.com
Background: Cadmium and lead are widespread and non-biodegradable pollutants of great
concern to human health. In real life scenarios, we are exposed to mixtures of chemicals …

Advances in metal-induced oxidative stress and human disease

K Jomova, M Valko - Toxicology, 2011 - Elsevier
Detailed studies in the past two decades have shown that redox active metals like iron (Fe),
copper (Cu), chromium (Cr), cobalt (Co) and other metals undergo redox cycling reactions …

Oxidative stress in lead and cadmium toxicity and its amelioration

RC Patra, AK Rautray, D Swarup - Veterinary medicine …, 2011 - Wiley Online Library
Oxidative stress has been implicated to play a role, at least in part, in pathogenesis of many
disease conditions and toxicities in animals. Overproduction of reactive oxygen species and …

Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage

N Ercal, H Gurer-Orhan… - Current topics in …, 2001 - ingentaconnect.com
Toxic metals (lead, cadmium, mercury and arsenic) are widely found in our environment.
Humans are exposed to these metals from numerous sources, including contaminated air …

Lead toxicity part II: the role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity.

L Patrick - Alternative medicine review, 2006 - search.ebscohost.com
Lead is an environmentally persistent toxin that causes neurological, hematological,
gastrointestinal, reproductive, circulatory, and immunological pathologies. The propensity for …

Antioxidant nutrients and lead toxicity

PC Hsu, YL Guo - Toxicology, 2002 - Elsevier
Lead-induced oxidative stress contributes to the pathogenesis of lead poisoning for
disrupting the delicate prooxidant/antioxidant balance that exists within mammalian cells …

Can antioxidants be beneficial in the treatment of lead poisoning?

H Gurer, N Ercal - Free Radical Biology and Medicine, 2000 - Elsevier
Recent studies have shown that lead causes oxidative stress by inducing the generation of
reactive oxygen species, reducing the antioxidant defense system of cells via depleting …

Low level lead exposure and oxidative stress: current opinions

M Ahamed, MKJ Siddiqui - Clinica chimica acta, 2007 - Elsevier
Lead continues to pose a serious threat to the health of many children as well as adults.
Concern about lead exposure as a significant public health problem has increased as …