Time-dependent diffusion magnetic resonance imaging: measurement, modeling, and applications

R Ba, L Kang, D Wu - Journal of Zhejiang University-SCIENCE A, 2024 - Springer
Increasingly, attention is being directed towards time-dependent diffusion magnetic
resonance imaging (TDDMRI), a method that reveals time-related changes in the diffusional …

[HTML][HTML] Cerebellar imaging with diffusion magnetic resonance imaging: approaches, challenges, and potential

H Lundell, CJ Steele - Current Opinion in Behavioral Sciences, 2024 - Elsevier
Highlights•The small size and tight packaging of the cerebellum makes dMRI challenging.•
Advancements in hardware, acquisition, and analyses hold promise for the cerebellum.•Non …

[HTML][HTML] Diffusion MRI with free gradient waveforms on a high-performance gradient system: Probing restriction and exchange in the human brain

A Chakwizira, A Zhu, T Foo, CF Westin… - NeuroImage, 2023 - Elsevier
The dependence of the diffusion MRI signal on the diffusion time carries signatures of
restricted diffusion and exchange. Here we seek to highlight these signatures in the human …

Water exchange rates measure active transport and homeostasis in neural tissue

NH Williamson, R Ravin, TX Cai, M Falgairolle… - PNAS …, 2023 - academic.oup.com
For its size, the brain is the most metabolically active organ in the body. Most of its energy
demand is used to maintain stable homeostatic physiological conditions. Altered …

Revealing membrane integrity and cell size from diffusion kurtosis time dependence

HH Lee, DS Novikov, E Fieremans… - Magnetic Resonance …, 2024 - Wiley Online Library
Purpose The nonmonotonic dependence of diffusion kurtosis on diffusion time has been
observed in biological tissues, yet its relation to membrane integrity and cellular geometry …

[HTML][HTML] Meningioma microstructure assessed by diffusion MRI: An investigation of the source of mean diffusivity and fractional anisotropy by quantitative histology

J Brabec, M Friedjungová, D Vašata, E Englund… - NeuroImage: Clinical, 2023 - Elsevier
Background Mean diffusivity (MD) and fractional anisotropy (FA) from diffusion MRI (dMRI)
have been associated with cell density and tissue anisotropy across tumors, but it is …

The Diffusion Exchange Ratio (DEXR): A minimal sampling of diffusion exchange spectroscopy to probe exchange, restriction, and time-dependence

TX Cai, NH Williamson, R Ravin, PJ Basser - Journal of Magnetic …, 2024 - Elsevier
Water exchange is increasingly recognized as an important biological process that can
affect the study of biological tissue using diffusion MR. Methods to measure exchange …

[HTML][HTML] Low-field, high-gradient NMR shows diffusion contrast consistent with localization or motional averaging of water near surfaces

NH Williamson, VJ Witherspoon, TX Cai… - Magnetic Resonance …, 2023 - Elsevier
Nuclear magnetic resonance (NMR) measurements of water diffusion have been extensively
used to probe microstructure in porous materials, such as biological tissue, however …

Cardiac q‐space trajectory imaging by motion‐compensated tensor‐valued diffusion encoding in human heart in vivo

I Teh, D Shelley, JH Boyle, F Zhou… - Magnetic …, 2023 - Wiley Online Library
Purpose Tensor‐valued diffusion encoding can probe more specific features of tissue
microstructure than what is available by conventional diffusion weighting. In this work, we …

Tuned exchange imaging: Can the filter exchange imaging pulse sequence be adapted for applications with thin slices and restricted diffusion?

S Lasič, A Chakwizira, H Lundell, CF Westin… - NMR in …, 2024 - Wiley Online Library
Filter exchange imaging (FEXI) is a double diffusion‐encoding (DDE) sequence that is
specifically sensitive to exchange between sites with different apparent diffusivities. FEXI …