Sepsis-associated brain injury: underlying mechanisms and potential therapeutic strategies for acute and long-term cognitive impairments

N Sekino, M Selim, A Shehadah - Journal of Neuroinflammation, 2022 - Springer
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. Sepsis causes cerebral dysfunction in the short and long term and induces …

Sepsis‐induced brain dysfunction: pathogenesis, diagnosis, and treatment

S Pan, Z Lv, R Wang, H Shu, S Yuan… - … medicine and cellular …, 2022 - Wiley Online Library
Dysregulated host response to infection, which cause life‐threatening organ dysfunction,
was defined as sepsis. Sepsis can cause acute and long‐term brain dysfunction, namely …

Central role of microglia in sepsis-associated encephalopathy: from mechanism to therapy

X Yan, K Yang, Q Xiao, R Hou, X Pan… - Frontiers in …, 2022 - frontiersin.org
Sepsis-associated encephalopathy (SAE) is a cognitive impairment associated with sepsis
that occurs in the absence of direct infection in the central nervous system or structural brain …

Autophagy suppresses ferroptosis by degrading TFR1 to alleviate cognitive dysfunction in mice with SAE

L Du, Y Wu, Q Jia, J Li, Y Li, H Ma, Z Fan, X Guo… - Cellular and molecular …, 2023 - Springer
Sepsis-associated encephalopathy (SAE) is a serious complication of sepsis that is
characterized by long-term cognitive impairment, which imposes a heavy burden on families …

Sepsis-associated muscle wasting: a comprehensive review from bench to bedside

I Yoshihara, Y Kondo, K Okamoto… - International Journal of …, 2023 - mdpi.com
Sepsis-associated muscle wasting (SAMW) is characterized by decreased muscle mass,
reduced muscle fiber size, and decreased muscle strength, resulting in persistent physical …

Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of sepsis-associated encephalopathy

JS Dumbuya, S Li, L Liang, Y Chen, J Du… - Journal of Translational …, 2022 - Springer
Background Sepsis-associated encephalopathy (SAE) is one of the most common types of
sepsis-related organ dysfunction without overt central nervous system (CNS) infection. It is …

PERK‐STING‐RIPK3 pathway facilitates cognitive impairment by inducing neuronal necroptosis in sepsis‐associated encephalopathy

G Xiaofeng, W You, J Qi, M Hongwei… - CNS neuroscience & …, 2023 - Wiley Online Library
Aims Sepsis‐associated encephalopathy (SAE) is a common but serious complication in
septic survivors and often causes long‐term cognitive impairments. The role of RIPK3 …

Paediatric sepsis-associated encephalopathy (SAE): a comprehensive review

JS Dumbuya, S Li, L Liang, Q Zeng - Molecular Medicine, 2023 - Springer
Sepsis-associated encephalopathy (SAE) is one of the most common types of organ
dysfunction without overt central nervous system (CNS) infection. It is associated with higher …

Exploring neuroprotective agents for sepsis-associated encephalopathy: A comprehensive review

K Krzyzaniak, R Krion, A Szymczyk… - International Journal of …, 2023 - mdpi.com
Sepsis is a life-threatening condition resulting from an inflammatory overreaction that is
induced by an infectious factor, which leads to multi-organ failure. Sepsis-associated …

Liensinine, a alkaloid from lotus plumule, mitigates lipopolysaccharide-induced sepsis-associated encephalopathy through modulation of nuclear factor erythroid 2 …

G Wang, Y Sun, Q Yang, D Dai, L Zhang, H Fan… - Food and Chemical …, 2023 - Elsevier
The present study aims to investigate the role of liensinine in life-threatened sepsis-
associated encephalopathy (SAE) mice and the underlying mechanism. Here, seventy-two …