G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and
an important class of drug targets, play a role in maintaining numerous physiological …

G protein-coupled receptors (GPCRs) are versatile and vital proteins involved in a wide
array of physiological processes and responses, such as sensory perception (eg, vision …

The complement system is a critical part of our innate immune response, and the terminal
products of this cascade, anaphylatoxins C3a and C5a, exert their physiological and …

The two non-visual arrestins, arrestin2 and arrestin3, bind hundreds of GPCRs with different
phosphorylation patterns, leading to distinct functional outcomes. Structural information on …

β-arrestins (βarrs) are multifunctional proteins involved in signaling and regulation of seven
transmembrane receptors (7TMRs), and their interaction is driven primarily by agonist …

Chemokine receptors constitute an important subfamily of G protein-coupled receptors
(GPCRs), and they are critically involved in a broad range of immune response …

Phosphorylated residues of G protein-coupled receptors bind to the N-domain of arrestin,
resulting in the release of its C-terminus. This induces further allosteric conformational …

More than 30 years after their discovery, arrestins are recognised multiprotein scaffolds that
play essential roles in G protein‐coupled receptor (GPCR) regulation and signalling …

SUMMARY Atypical chemokine receptor 3 (ACKR3, also known as CXCR7) is a scavenger
receptor that regulates extracellular levels of the chemokine CXCL12 to maintain …

GPR101 is an orphan G protein-coupled receptor that promotes growth hormone secretion
in the pituitary. The microduplication of the GPR101 gene has been linked with the X-linked …