Looking at the variety of the thousands of different polypeptides that have been focused on
in the research on the endoplasmic reticulum from the last five decades taught us one …

The endoplasmic reticulum (ER) is a complex, multifunctional organelle comprised of a
continuous membrane and lumen that is organized into a number of functional regions. It …

Membrane protein biogenesis poses acute challenges to protein homeostasis, and how they
are selectively escorted to the target membrane is not well understood. Here we address this …

The targeting and insertion of tail-anchored (TA) integral membrane proteins (IMPs) into the
correct membrane is critical for cellular homeostasis. The fungal protein Sgt2, and its human …

Chemical mutagenesis via dehydroalanine (Dha) is a powerful method to tailor protein
structure and function, allowing the site-specific installation of post-translational …

Intracellular aggregates are a common pathological hallmark of neurodegenerative
diseases such as polyglutamine (polyQ) diseases, amyotrophic lateral sclerosis (ALS) …

Mislocalised membrane proteins (MLPs) present a risk to the cell due to exposed
hydrophobic amino acids which cause MLPs to aggregate. Previous studies identified SGTA …

The heterotrimeric BAG6 complex coordinates the direct handover of newly synthesised tail-
anchored (TA) membrane proteins from an SGTA-bound preloading complex to the …

SGTs (small glutamine-rich TPR-containing proteins) are dimeric proteins that belong to the
class of co-chaperones characterized by the presence of TPR domains (containing …

The correct targeting and insertion of tail-anchored (TA) integral membrane proteins (IMP) is
critical for cellular homeostasis. The mammalian protein SGTA, and its fungal homolog Sgt2 …