Decades of research have identified genetic factors and biochemical pathways involved in
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …

Aging is a physiological process mediated by numerous biological and genetic pathways,
which are directly linked to lifespan and are a driving force for all age-related diseases …

Gene expression profiling has identified numerous processes altered in aging, but how
these changes arise is largely unknown. Here we combined nascent RNA sequencing and …

DNA is the source of genetic information, and preserving its integrity is essential in order to
sustain life. The genome is continuously threatened by different types of DNA lesions, such …

Damaged deoxyribonucleic acid (DNA) is a primary pathologic factor for osteoarthritis (OA);
however, the mechanism by which DNA damage drives OA is unclear. Previous research …

In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …

The neuronal genome is particularly sensitive to loss or attenuation of DNA repair, and many
neurological diseases ensue when DNA repair is impaired. It is well-established that the …

DNA damage is the cause of numerous human pathologies including cancer, premature
aging, and chronic inflammatory conditions. The DNA damage response (DDR), in turn …

The discovery of the DNA double helix has revolutionized our understanding of data
processing in living systems, with the complementarity of the two DNA strands providing a …

Abstract The US Food and Drug Administration recently approved two poly‐adenosine
diphosphate‐ribose polymerase (PARP) inhibitors, olaparib and rucaparib, for treatment of …