Emerging data indicate that neurological complications occur as a consequence of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The blood–brain barrier …

The consequences of cerebrovascular disease are among the leading health issues
worldwide. Large and small cerebral vessel disease can trigger stroke and contribute to the …

Brain endothelial cells form a paracellular and transcellular barrier to many blood-borne
solutes via tight junctions (TJs) and scarce endocytotic vesicles. The blood-brain barrier …

Blood vessels are critical to deliver oxygen and nutrients to tissues and organs throughout
the body. The blood vessels that vascularize the central nervous system (CNS) possess …

The blood–brain barrier (BBB) is a highly regulated and efficient barrier that provides a
sanctuary to the brain. It is designed to regulate brain homeostasis and to permit selective …

The blood-brain barrier (BBB) is the regulated interface between the peripheral circulation
and the central nervous system (CNS). Although originally observed by Paul Ehrlich in 1885 …

Transient or permanent interruption of cerebral blood flow by occlusion of a cerebral artery
gives rise to an ischaemic stroke leading to irreversible damage or dysfunction to the cells …

The market for neuropharmaceuticals is potentially one of the largest sectors of the global
pharmaceutical market owing to the increase in average life expectancy and the fact that …

The blood-brain barrier (BBB) is an active interface between the circulation and the central
nervous system (CNS) with a dual function: the barrier function restricts the transport from …

Ischemic stroke and ischemia/reperfusion (I/R) injury induced by thrombolytic therapy are
conditions with high mortality and serious long-term physical and cognitive disabilities. They …