The unresolved pathophysiology of lymphedema
SH Azhar, HY Lim, BK Tan, V Angeli - Frontiers in physiology, 2020 - frontiersin.org
Lymphedema is the clinical manifestation of impaired lymphatic transport. It remains an
under-recognized and under-documented clinical condition that still lacks a cure. Despite …
under-recognized and under-documented clinical condition that still lacks a cure. Despite …
Inflammatory manifestations of lymphedema
Lymphedema results from lymphatic insufficiency leading to a progressive inflammatory
process that ultimately manifests as discomfort, recurrent infections, and, at times, secondary …
process that ultimately manifests as discomfort, recurrent infections, and, at times, secondary …
[HTML][HTML] Lymphatics act as a signaling hub to regulate intestinal stem cell activity
Barrier epithelia depend upon resident stem cells for homeostasis, defense, and repair.
Epithelial stem cells of small and large intestines (ISCs) respond to their local …
Epithelial stem cells of small and large intestines (ISCs) respond to their local …
TGF‐β1 mediates pathologic changes of secondary lymphedema by promoting fibrosis and inflammation
Background Secondary lymphedema is a common complication of cancer treatment, and
previous studies have shown that the expression of transforming growth factor‐beta 1 (TGF …
previous studies have shown that the expression of transforming growth factor‐beta 1 (TGF …
Regulation of immune function by the lymphatic system in lymphedema
The lymphatic vasculature has traditionally been thought to play a passive role in the
regulation of immune responses by transporting antigen presenting cells and soluble …
regulation of immune responses by transporting antigen presenting cells and soluble …
The vicious circle of stasis, inflammation, and fibrosis in lymphedema
Lymphedema is a progressive disease of the lymphatic system arising from impaired
lymphatic drainage, accumulation of interstitial fluid, and fibroadipose deposition. Secondary …
lymphatic drainage, accumulation of interstitial fluid, and fibroadipose deposition. Secondary …
Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema
D Szőke, G Kovács, É Kemecsei, L Bálint… - Nature …, 2021 - nature.com
Lack or dysfunction of the lymphatics leads to secondary lymphedema formation that
seriously reduces the function of the affected organs and results in degradation of quality of …
seriously reduces the function of the affected organs and results in degradation of quality of …
Fibrosis and secondary lymphedema: chicken or egg?
Secondary lymphedema is a common complication of cancer treatment resulting in
progressive fibroadipose tissue deposition, increased risk of infections, and, in rare cases …
progressive fibroadipose tissue deposition, increased risk of infections, and, in rare cases …
Histopathologic features of lymphedema: a molecular review
CY Li, RP Kataru, BJ Mehrara - International journal of molecular sciences, 2020 - mdpi.com
An estimated 5 million people in the United States are affected by secondary lymphedema,
with most cases attributed to malignancies or malignancy-related treatments. The …
with most cases attributed to malignancies or malignancy-related treatments. The …
Emerging anti-inflammatory pharmacotherapy and cell-based therapy for lymphedema
R Ogino, T Yokooji, M Hayashida, S Suda… - International Journal of …, 2022 - mdpi.com
Secondary lymphedema is a common complication of lymph node dissection or radiation
therapy for cancer treatment. Conventional therapies such as compression sleeve therapy …
therapy for cancer treatment. Conventional therapies such as compression sleeve therapy …