The unresolved pathophysiology of lymphedema

SH Azhar, HY Lim, BK Tan, V Angeli - Frontiers in physiology, 2020 - frontiersin.org
Lymphedema is the clinical manifestation of impaired lymphatic transport. It remains an
under-recognized and under-documented clinical condition that still lacks a cure. Despite …

Inflammatory manifestations of lymphedema

CL Ly, RP Kataru, BJ Mehrara - International journal of molecular …, 2017 - mdpi.com
Lymphedema results from lymphatic insufficiency leading to a progressive inflammatory
process that ultimately manifests as discomfort, recurrent infections, and, at times, secondary …

[HTML][HTML] Lymphatics act as a signaling hub to regulate intestinal stem cell activity

RE Niec, T Chu, M Schernthanner, S Gur-Cohen… - Cell stem cell, 2022 - cell.com
Barrier epithelia depend upon resident stem cells for homeostasis, defense, and repair.
Epithelial stem cells of small and large intestines (ISCs) respond to their local …

TGF‐β1 mediates pathologic changes of secondary lymphedema by promoting fibrosis and inflammation

JE Baik, HJ Park, RP Kataru, IL Savetsky… - Clinical and …, 2022 - Wiley Online Library
Background Secondary lymphedema is a common complication of cancer treatment, and
previous studies have shown that the expression of transforming growth factor‐beta 1 (TGF …

Regulation of immune function by the lymphatic system in lymphedema

RP Kataru, JE Baik, HJ Park, I Wiser, S Rehal… - Frontiers in …, 2019 - frontiersin.org
The lymphatic vasculature has traditionally been thought to play a passive role in the
regulation of immune responses by transporting antigen presenting cells and soluble …

The vicious circle of stasis, inflammation, and fibrosis in lymphedema

S Brown, JH Dayan, RP Kataru… - Plastic and …, 2023 - journals.lww.com
Lymphedema is a progressive disease of the lymphatic system arising from impaired
lymphatic drainage, accumulation of interstitial fluid, and fibroadipose deposition. Secondary …

Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema

D Szőke, G Kovács, É Kemecsei, L Bálint… - Nature …, 2021 - nature.com
Lack or dysfunction of the lymphatics leads to secondary lymphedema formation that
seriously reduces the function of the affected organs and results in degradation of quality of …

Fibrosis and secondary lymphedema: chicken or egg?

RP Kataru, I Wiser, JE Baik, HJ Park, S Rehal… - Translational …, 2019 - Elsevier
Secondary lymphedema is a common complication of cancer treatment resulting in
progressive fibroadipose tissue deposition, increased risk of infections, and, in rare cases …

Histopathologic features of lymphedema: a molecular review

CY Li, RP Kataru, BJ Mehrara - International journal of molecular sciences, 2020 - mdpi.com
An estimated 5 million people in the United States are affected by secondary lymphedema,
with most cases attributed to malignancies or malignancy-related treatments. The …

Emerging anti-inflammatory pharmacotherapy and cell-based therapy for lymphedema

R Ogino, T Yokooji, M Hayashida, S Suda… - International Journal of …, 2022 - mdpi.com
Secondary lymphedema is a common complication of lymph node dissection or radiation
therapy for cancer treatment. Conventional therapies such as compression sleeve therapy …