Present application and perspectives of organoid imaging technology

K Fei, J Zhang, J Yuan, P Xiao - Bioengineering, 2022 - mdpi.com
An organoid is a miniaturized and simplified in vitro model with a similar structure and
function to a real organ. In recent years, the use of organoids has increased explosively in …

Creating mini-pregnancy models in vitro with clinical perspectives

JY Park, H Lim, J Qin, LP Lee - EBioMedicine, 2023 - thelancet.com
During the last decade, organs-on-chips or organoids microphysiological analysis platforms
(MAP) have garnered attention in the practical applications of disease models, drug …

Longitudinal morphological and functional characterization of human heart organoids using optical coherence tomography

Y Ming, S Hao, F Wang, YR Lewis-Israeli… - Biosensors and …, 2022 - Elsevier
Organoids play an increasingly important role as in vitro models for studying organ
development, disease mechanisms, and drug discovery. Organoids are self-organizing …

Ultrasound-induced reorientation for multi-angle optical coherence tomography

M Kvåle Løvmo, S Deng, S Moser, R Leitgeb… - Nature …, 2024 - nature.com
Organoid and spheroid technology provide valuable insights into developmental biology
and oncology. Optical coherence tomography (OCT) is a label-free technique that has …

Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography

R Leitgeb, F Placzek, E Rank, L Krainz… - Journal of …, 2021 - spiedigitallibrary.org
Significance: After three decades, more than 75,000 publications, tens of companies being
involved in its commercialization, and a global market perspective of about USD 1.5 billion …

Time-domain full-field optical coherence tomography (TD-FF-OCT) in ophthalmic imaging

J Zhang, V Mazlin, K Fei, AC Boccara… - … in Chronic Disease, 2023 - journals.sagepub.com
Ocular imaging plays an irreplaceable role in the evaluation of eye diseases. Developing
cellular-resolution ophthalmic imaging technique for more accurate and effective diagnosis …

Revealing the clinical potential of high-resolution organoids

J Ko, S Hyung, S Cheong, Y Chung, NL Jeon - Advanced Drug Delivery …, 2024 - Elsevier
The symbiotic interplay of organoid technology and advanced imaging strategies yields
innovative breakthroughs in research and clinical applications. Organoids, intricate three …

Automated detection and growth tracking of 3D bio-printed organoid clusters using optical coherence tomography with deep convolutional neural networks

D Bao, L Wang, X Zhou, S Yang, K He… - … in Bioengineering and …, 2023 - frontiersin.org
Organoids are advancing the development of accurate prediction of drug efficacy and
toxicity in vitro. These advancements are attributed to the ability of organoids to recapitulate …

Quantifying the drug response of patient-derived organoid clusters by aggregated morphological indicators with multi-parameters based on optical coherence …

L Zhang, L Wang, S Yang, K He, D Bao… - Biomedical Optics …, 2023 - opg.optica.org
Patient-derived organoids (PDOs) serve as excellent tools for personalized drug screening
to predict clinical outcomes of cancer treatment. However, current methods for efficient …

Deep learning based characterization of human organoids using optical coherence tomography

B Wang, R Ganjee, I Khandaker, K Flohr… - Biomedical Optics …, 2024 - opg.optica.org
Organoids, derived from human induced pluripotent stem cells (hiPSCs), are intricate three-
dimensional in vitro structures that mimic many key aspects of the complex morphology and …