Zebrafish have several advantages compared to other vertebrate models used in modeling
human diseases, particularly for large-scale genetic mutant and therapeutic compound …

Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left
ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle …

When faced with increased workload the heart undergoes remodelling, where it increases
its muscle mass in an attempt to preserve normal function. This is referred to as cardiac …

Objective Astrocytes actively participate in energy metabolism in the brain, and astrocytic
aerobic glycolysis disorder is associated with the pathology of Alzheimer's disease (AD) …

Cardiac hypertrophy is frequently associated with ventricular dysfunction and heart failure.
Paeoniflorin, has been widely used to treat cardiovascular dysfunction-related diseases …

The mercapturic acid pathway is a major route for the biotransformation of xenobiotic and
endobiotic electrophilic compounds and their metabolites. Mercapturic acids (N-acetyl-l …

Hypertrophic cardiomyopathy (HCM) is a genetic heart disease that is characterized by
unexplained segmental hypertrophy that is usually most pronounced in the septum. While …

Background Cardiomyopathies are a heterogeneous group of heart diseases that can
gradually cause severe heart failure. In particular, dilated cardiomyopathy (DCM) and …

The failing heart is characterized by elevated levels of reactive oxygen species. We have
developed an animal model of heart failure induced by chemogenetic production of …

Background The mitochondrial associated endoplasmic reticulum (ER) membrane (MAM)
provides a platform for communication between the mitochondria and ER, and it plays a vital …