Metformin is an oral antihyperglycemic drug widely used to treat type 2 diabetes mellitus
(T2DM), acting via indirect activation of 5′ Adenosine monophosphate-activated Protein …

Ciliopathies are a family of rather diverse conditions, which have been grouped based on
the finding of altered or dysfunctional cilia, potentially motile, small cellular antennae …

Treatment with sodium-glucose cotransporter-2 (SGLT2) inhibitors may have pleiotropic and
beneficial effects in terms of ameliorating of risk factors for the progression of autosomal …

Introduction Autosomal dominant polycystic kidney disease (ADPKD) is the most common
inherited kidney disease that leads to eventual renal failure. Metformin (MET), an AMP …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common congenital
kidney disorder, generally caused by mutations in the PKD1 and PKD2 genes, coding for …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common Mendelian
kidney disease, affecting approximately one in 1,000 births and accounting for 5% of end …

Polycystic Kidney Disease (PKD) refers to a group of disorders, driven by the formation of
cysts in renal tubular cells and is currently one of the leading causes of end-stage renal …

Introduction Renal ciliopathies represent a collection of genetic disorders characterized by
deficiencies in the biogenesis, maintenance, or functioning of the ciliary complex. These …

Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent single-gene
disorder leading to renal failure. Current therapies are aimed to treat renal and extrarenal …

Polycystic kidney disease (PKD) is a genetic disorder characterized by aberrant renal
epithelial cell proliferation and formation and progressive growth of numerous fluid‐filled …