Colorectal cancer (CRC) is a prevalent malignancy of the digestive tract with the second
highest mortality rate globally. Piper nigrum is a widely used traditional medicinal plant …

Two different series of fifty-two compounds, based on 3′, 4′, 5′-trimethoxyaniline (7a–
ad) and variably substituted anilines (8a–v) at the 7-position of the 2-substituted-[1, 2, 4] …

With cancer as one of the leading causes of death worldwide, there is a need for the
development of accurate, cost-effective, easy-to-use, and fast drug-testing assays. While the …

High expression of polo‑like kinase 4 (PLK4) promotes tumorigenesis and is correlated with
poor prognosis in several kinds of cancer. However, the prognostic value of PLK4 in …

Background Tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is an
apoptosis inducer that exhibits an ideal therapeutic safety profile with less adverse effects …

Due to cancer heterogeneity, only some patients can benefit from drug therapy. The
personalized drug usage is important for improving the treatment response rate of cancer …

There are several studies on biological activities of echinoderms' secondary metabolites.
Sea cucumbers are known to contain natural products with biological activities. Different sea …

The present study evaluated the efficiency, prognostic factors for and the safety of irinotecan
combined with raltitrexed (TOMIRI) in patients with metastatic colorectal cancer (CRC) …

Monitoring cells on substrates time-continuously without relying on optical microscopy
imaging is of broad interest in biotechnological applications. We propose an approach to …

肝癌是中国临床上常见的恶性肿瘤, 包括原发性肝癌和继发性肝癌. 在最近的十几年内,
经肝动脉灌注化疗(hepatic arterial infusion chemotherapy, HAIC) 在肝癌的临床治疗中显示出 …