Therapeutic significance of β-glucuronidase activity and its inhibitors: A review
The emergence of disease and dearth of effective pharmacological agents on most
therapeutic fronts, constitutes a major threat to global public health and man's existence …
therapeutic fronts, constitutes a major threat to global public health and man's existence …
Synthesis of alpha amylase inhibitors based on privileged indole scaffold
Twenty five derivatives of indole carbohydrazide (1–25) had been synthesized. These
compounds were characterized using 1 H NMR and EI-MS, and further evaluated for their α …
compounds were characterized using 1 H NMR and EI-MS, and further evaluated for their α …
Synthesis, molecular docking study and in vitro thymidine phosphorylase inhibitory potential of oxadiazole derivatives
We have synthesized oxadiazole derivatives (1–16), characterized by 1 H NMR, 13 C NMR
and HREI-MS and screened for thymidine phosphorylase inhibitory potential. All derivatives …
and HREI-MS and screened for thymidine phosphorylase inhibitory potential. All derivatives …
Redox-mediated and microwave-assisted thiol activation: two approaches to unsymmetrical disulfides synthesis
DA Burmistrova, A Galustyan… - Journal of The …, 2022 - iopscience.iop.org
Two approaches to synthesis of unsymmetrical disulfides based on different types of thiol
activation, namely, an electrochemical method in the presence of a redox mediator and a …
activation, namely, an electrochemical method in the presence of a redox mediator and a …
Synthesis of indole analogs as potent β-glucuronidase inhibitors
Natural products are the main source of motivation to design and synthesize new molecules
for drug development. Designing new molecules against β-glucuronidase inhibitory is …
for drug development. Designing new molecules against β-glucuronidase inhibitory is …
Synthesis, molecular docking and β-glucuronidase inhibitory potential of indole base oxadiazole derivatives
β-glucuronidase is a lysosomal glycosidase enzyme which catalyzes the extracellular matrix
of cancer and normal cells and the glycosaminoglycans of the cell membrane, which is …
of cancer and normal cells and the glycosaminoglycans of the cell membrane, which is …
Synthesis, in vitro β-glucuronidase inhibitory potential and molecular docking studies of quinolines
In this study synthesis and β-glucuronidase inhibitory potential of 3/5/8 sulfonamide and 8-
sulfonate derivatives of quinoline (1–40) are discussed. Studies reveal that all the synthetic …
sulfonate derivatives of quinoline (1–40) are discussed. Studies reveal that all the synthetic …
Synthesis and biological evaluation of disulfides bearing 1, 2, 4-triazole moiety as antiproliferative agents
XF Wang, S Zhang, BL Li, JJ Zhao, YM Liu… - Medicinal Chemistry …, 2017 - Springer
A series of novel nonsymmetrical disulfides bearing 1, 2, 4-triazole moiety were designed,
synthesized, and evaluated for their in vitro antiproliferative activities against human cancer …
synthesized, and evaluated for their in vitro antiproliferative activities against human cancer …
Selective N-acetylation with concurrent S-oxidation of o-amino thiol at ambient conditions over Ce doped ZnO composite nanocrystallites
The oxidative Ssingle bondS coupling of thiol to disulfide is an imperative chemical
transformation in the domain of biological processes and also finds numerous chemical …
transformation in the domain of biological processes and also finds numerous chemical …
肠道菌β-葡萄糖醛酸苷酶抑制剂的研究进展
翁仔淼， 吕珊珊， 葛广波， 王平， 侯洁 - 药学进展, 2018 - pps.cpu.edu.cn
β-葡萄糖醛酸苷酶(GUS) 是肠道菌群产生的一类重要的水解酶, 其可催化多种药物及内源性激素
的葡萄糖醛酸苷发生水解反应. 研究显示肠道菌GUS 可影响多种药物的药代动力学行为和效应 …
的葡萄糖醛酸苷发生水解反应. 研究显示肠道菌GUS 可影响多种药物的药代动力学行为和效应 …