Background Psychological treatments occupy an important place in evidence-based mental
health treatments. Now is an exciting time to fuel treatment research: a pressing demand for …

The ventromedial prefrontal cortex (vmPFC) has been implicated in a variety of social,
cognitive, and affective functions that are commonly disrupted in mental illness. In this …

Objective: Loss of pleasure or interest in activities (ie, anhedonia) is a risk factor for
suicidality, treatment nonresponse, and relapse. Extant treatments that focus on reducing …

Objective: Determine whether a novel psychosocial treatment for positive affect improves
clinical status and reward sensitivity more than a form of cognitive behavioral therapy that …

Anhedonia, or loss of interest or pleasure in usual activities, is characteristic of depression,
some types of anxiety, as well as substance abuse and schizophrenia. Anhedonia is a …

Motivational and motor deficits are common in patients with depression and other psychiatric
disorders, and are related to symptoms of anhedonia and motor retardation. These deficits in …

Depression is a significant public health problem, but its etiology and pathophysiology
remain poorly understood. Such incomplete understanding likely arises from the fact that …

Anhedonia is a core symptom of major depressive disorder (MDD), the neurobiological
mechanisms of which remain poorly understood. Despite decades of speculation regarding …

Importance Major depressive disorder is prevalent and impairing. Parsing
neurocomputational substrates of reinforcement learning in individuals with depression may …

Pleasure and motivation are important factors for goal-directed behavior and well-being in
both animals and humans. Intact hedonic capacity requires an undisturbed interplay …