Zinc is a ubiquitous biological metal in all living organisms. The spatiotemporal zinc
dynamics in cells provide crucial cellular signaling opportunities, but also challenges for …

Manganese (Mn) is an essential nutrient for intracellular activities; it functions as a cofactor
for a variety of enzymes, including arginase, glutamine synthetase (GS), pyruvate …

Manganese (Mn) is an essential micronutrient required for the normal development of many
organs, including the brain. Although its roles as a cofactor in several enzymes and in …

Alzheimer's disease and related dementias lack effective treatment or cures and are major
public health challenges. Risk for Alzheimer's disease and related dementias is partially …

Zinc (Zn) is an essential trace mineral that regulates the expression and activation of
biological molecules such as transcription factors, enzymes, adapters, channels, and growth …

Significance: Essential metals such as copper, iron, manganese, and zinc play a role as
cofactors in the activity of a wide range of processes involved in cellular homeostasis and …

Essential trace elements play pivotal roles in numerous structural and catalytic functions of
proteins. Adequate intake of essential trace elements from the daily diet is indispensable to …

Among the biologically required first row, late d-block metals from Mn II to Zn II, the catalytic
and structural reach of Zn II ensures that this essential micronutrient touches nearly every …

Zinc transporter 1 (ZNT1) is the only zinc transporter predominantly located on the plasma
membrane, where it plays a pivotal role exporting cytosolic zinc to the extracellular space …

Solute carrier family 39, member 14 (SLC39A14) is a transmembrane transporter that can
mediate the cellular uptake of zinc, iron, and manganese (Mn). Studies of Slc39a14 …