It has been more than a century since Pío del Río‐Hortega first characterized microglia in
histological stains of brain tissue. Since then, significant advances have been made in …

The cerebral cortex is the brain's outermost layer. It is responsible for processing motor and
sensory information that support high-level cognitive abilities and shape personality. Its …

The R47H variant of triggering receptor expressed on myeloid cells 2 (TREM2) increases
the risk of Alzheimer's disease (AD). To investigate potential mechanisms, we analyzed …

Astrocytes play essential roles in the developing nervous system, including supporting
synapse function. These astrocyte support functions emerge coincident with brain …

The innate immune system shapes brain development and is implicated in
neurodevelopmental diseases. It is critical to define the relevant immune cells and signals …

Microglia play a crucial role in interacting with neuronal synapses and modulating synaptic
plasticity. This function is particularly significant during postnatal development, as microglia …

Microglia are brain-resident macrophages that play key roles in brain development and
experience dependent plasticity. In this review we discuss recent findings regarding the …

Highlights•Neurodevelopmental disorders (NDDs) arise from errors in synaptic circuit
development.•Astrocytes communicate bidirectionally with neurons to control synapse …

High-resolution omics, particularly single-cell and spatial transcriptomic profiling, are rapidly
enhancing our comprehension of the normal molecular diversity of gliovascular cells, as well …

Microglia play diverse pathophysiological roles in Alzheimer's disease (AD), with genetic
susceptibility factors skewing microglial cell function to influence AD risk. CD33 is an …