Metal-catalyzed reductive coupling has emerged as an alternative to the use of
stoichiometric organometallic reagents in an increasingly diverse range of carbonyl and …

Atom-efficient processes that occur via addition, redistribution, or removal of hydrogen
underlie many large-volume industrial processes and pervade all segments of chemical …

The use of alkynes as vinylmetal pronucleophiles in intermolecular enantioselective metal-
catalyzed carbonyl and imine reductive couplings to form allylic alcohols and amines is …

Bryostatins are a class of naturally occurring macrocyclic lactones with a unique fast
developing portfolio of clinical applications, including treatment of AIDS, Alzheimer's …

The development and application of stereoselective and site-selective catalytic methods that
directly convert lower alcohols to higher alcohols are described. These processes merge the …

The goal of this review is to highlight the applications of carbonylation reactions of alkenes
in the total synthesis of natural compounds. These highly atom-economic reactions, which …

Microglia and CNS-infiltrating macrophages play significant roles in the pathogenesis of
neuroinflammatory and neurodegenerative diseases, such as Alzheimer's disease …

The synthesis and biological evaluation of chromane-containing bryostatin analogues WN-2–
WN-7 and the previously reported salicylate-based analogue WN-8 are described …

The synthesis of des-epoxy-amphidinolide N was achieved in 22 longest linear and 33 total
steps. Three generations of synthetic endeavors are reported herein. During the first …

Protein kinase C (PKC) modulators are currently of great importance in preclinical and
clinical studies directed at cancer, immunotherapy, HIV eradication, and Alzheimer's …