The methods for the culture and cardiomyocyte differentiation of human embryonic stem
cells, and later human induced pluripotent stem cells (hiPSC), have moved from a complex …

Background Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have
emerged as a powerful tool for disease modeling, though their immature nature currently …

Pluripotent stem cell-derived organoids can recapitulate significant features of organ
development in vitro. We hypothesized that creating human heart organoids by mimicking …

The number one cause of human fetal death are defects in heart development. Because the
human embryonic heart is inaccessible and the impacts of mutations, drugs, and …

The cardiomyocyte (CM) subtypes in the mammalian heart derive from distinct lineages
known as the first heart field (FHF), the anterior second heart field (aSHF), and the posterior …

Pluripotent stem-cell-derived cardiomyocytes (PSC-CMs) provide an unprecedented
opportunity to study human heart development and disease, but they are functionally and …

Cardiac fibroblasts play an essential role in the development of the heart and are implicated
in disease progression in the context of fibrosis and regeneration. Here, we establish a …

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have wide
potential application in basic research, drug discovery, and regenerative medicine, but …

Cell-based therapies offer an exciting and novel treatment for heart repair following
myocardial infarction (MI). However, these therapies often suffer from poor cell viability and …

Estrogen-related receptors (ERR) α and γ were shown recently to serve as regulators of
cardiac maturation, yet the underlying mechanisms have not been delineated. Herein, we …