High-throughput and single-cell T cell receptor sequencing technologies
JA Pai, AT Satpathy - Nature methods, 2021 - nature.com
T cells express T cell receptors (TCRs) composed of somatically recombined TCRα and
TCRβ chains, which mediate recognition of major histocompatibility complex (MHC)–antigen …
TCRβ chains, which mediate recognition of major histocompatibility complex (MHC)–antigen …
The diverse functions of the PD1 inhibitory pathway
AH Sharpe, KE Pauken - Nature Reviews Immunology, 2018 - nature.com
T cell activation is a highly regulated process involving peptide–MHC engagement of the T
cell receptor and positive costimulatory signals. Upon activation, coinhibitory'checkpoints' …
cell receptor and positive costimulatory signals. Upon activation, coinhibitory'checkpoints' …
[HTML][HTML] MYB orchestrates T cell exhaustion and response to checkpoint inhibition
C Tsui, L Kretschmer, S Rapelius, SS Gabriel… - Nature, 2022 - nature.com
CD8+ T cells that respond to chronic viral infections or cancer are characterized by the
expression of inhibitory receptors such as programmed cell death protein 1 (PD-1) and by …
expression of inhibitory receptors such as programmed cell death protein 1 (PD-1) and by …
Clonal expansion and epigenetic inheritance of long-lasting NK cell memory
Clonal expansion of cells with somatically diversified receptors and their long-term
maintenance as memory cells is a hallmark of adaptive immunity. Here, we studied …
maintenance as memory cells is a hallmark of adaptive immunity. Here, we studied …
Therapeutic T cell engineering
M Sadelain, I Rivière, S Riddell - Nature, 2017 - nature.com
Genetically engineered T cells are powerful new medicines, offering hope for curative
responses in patients with cancer. Chimaeric antigen receptors (CARs) are a class of …
responses in patients with cancer. Chimaeric antigen receptors (CARs) are a class of …
Effector CD8 T cells dedifferentiate into long-lived memory cells
Memory CD8 T cells that circulate in the blood and are present in lymphoid organs are an
essential component of long-lived T cell immunity. These memory CD8 T cells remain …
essential component of long-lived T cell immunity. These memory CD8 T cells remain …
Adoptive cell transfer as personalized immunotherapy for human cancer
SA Rosenberg, NP Restifo - Science, 2015 - science.org
Adoptive cell therapy (ACT) is a highly personalized cancer therapy that involves
administration to the cancer-bearing host of immune cells with direct anticancer activity. ACT …
administration to the cancer-bearing host of immune cells with direct anticancer activity. ACT …
Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivo
D Sommermeyer, M Hudecek, PL Kosasih, T Gogishvili… - Leukemia, 2016 - nature.com
Adoptive T-cell therapy with gene-modified T cells expressing a tumor-reactive T-cell
receptor or chimeric antigen receptor (CAR) is a rapidly growing field of translational …
receptor or chimeric antigen receptor (CAR) is a rapidly growing field of translational …
T memory stem cells in health and disease
T memory stem (TSCM) cells are a rare subset of memory lymphocytes endowed with the
stem cell–like ability to self-renew and the multipotent capacity to reconstitute the entire …
stem cell–like ability to self-renew and the multipotent capacity to reconstitute the entire …
Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function
The mechanisms underlying human natural killer (NK) cell phenotypic and functional
heterogeneity are unknown. Here, we describe the emergence of diverse subsets of human …
heterogeneity are unknown. Here, we describe the emergence of diverse subsets of human …