Strengths, weaknesses, opportunities and challenges for long acting injectable therapies: Insights for applications in HIV therapy
A Owen, S Rannard - Advanced drug delivery reviews, 2016 - Elsevier
Advances in solid drug nanoparticle technologies have resulted in a number of long-acting
(LA) formulations with the potential for once monthly or longer administration. Such …
(LA) formulations with the potential for once monthly or longer administration. Such …
[HTML][HTML] Nanoneuromedicines for degenerative, inflammatory, and infectious nervous system diseases
Interest in nanoneuromedicine has grown rapidly due to the immediate need for improved
biomarkers and therapies for psychiatric, developmental, traumatic, inflammatory, infectious …
biomarkers and therapies for psychiatric, developmental, traumatic, inflammatory, infectious …
[HTML][HTML] Sequential LASER ART and CRISPR treatments eliminate HIV-1 in a subset of infected humanized mice
Elimination of HIV-1 requires clearance and removal of integrated proviral DNA from
infected cells and tissues. Here, sequential long-acting slow-effective release antiviral …
infected cells and tissues. Here, sequential long-acting slow-effective release antiviral …
Transformation of tenofovir into stable ProTide nanocrystals with long-acting pharmacokinetic profiles
Abstract Treatment and prevention of human immunodeficiency virus type one (HIV-1)
infection was transformed through widespread use of antiretroviral therapy (ART). However …
infection was transformed through widespread use of antiretroviral therapy (ART). However …
Creation of a long-acting nanoformulated dolutegravir
Potent antiretroviral activities and a barrier to viral resistance characterize the human
immunodeficiency virus type one (HIV-1) integrase strand transfer inhibitor dolutegravir …
immunodeficiency virus type one (HIV-1) integrase strand transfer inhibitor dolutegravir …
[HTML][HTML] Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles
Long-acting parenteral (LAP) antiretroviral drugs have generated considerable interest for
treatment and prevention of HIV-1 infection. One new LAP is cabotegravir (CAB), a highly …
treatment and prevention of HIV-1 infection. One new LAP is cabotegravir (CAB), a highly …
Queueing theory model of pentose phosphate pathway
Due to its role in maintaining the proper functioning of the cell, the pentose phosphate
pathway (PPP) is one of the most important metabolic pathways. It is responsible for …
pathway (PPP) is one of the most important metabolic pathways. It is responsible for …
Cutting edge strategies for screening of novel anti-HIV drug candidates against HIV infection: a concise overview of cell based assays
SY Gaikwad, P Phatak, A Mukherjee - Heliyon, 2023 - cell.com
Abstract The advent of Highly Active Antiretroviral Therapy has majorly contributed towards
reducing the morbidity and mortality associated with HIV infected people, thus improving the …
reducing the morbidity and mortality associated with HIV infected people, thus improving the …
The promise of long-acting antiretroviral therapies: from need to manufacture
Antiretroviral therapy has transformed human immunodeficiency virus infections from certain
death to a manageable chronic disease. Achieving strict adherence to drug regimens that …
death to a manageable chronic disease. Achieving strict adherence to drug regimens that …
[HTML][HTML] Anti-retroviral drugs: current state and development in the next decade
X Zhang - Acta pharmaceutica sinica B, 2018 - Elsevier
The pace of discovery of new antiretroviral (ARV) drugs has slowed, although the efficacy
and safety of once-daily fixed dose combinations have been extensively investigated …
and safety of once-daily fixed dose combinations have been extensively investigated …