Sphingolipids, including the two central bioactive lipids ceramide and sphingosine-1-
phosphate (S1P), have opposing roles in regulating cancer cell death and survival …

The potent pleiotropic lipid mediator sphingosine-1-phosphate (S1P) participates in
numerous cellular processes, including angiogenesis and cell survival, proliferation, and …

Background Osteosarcoma (OS) is a malignant tumor mainly occurring in young people.
Due to the limited effective therapeutic strategies, OS patients cannot achieve further …

Sphingosine-1-phosphate (S1P), via its G-protein-coupled receptors, is a signaling molecule
with important regulatory properties on numerous, widely varied cell types. Five S1P …

Simple Summary Sphingolipids, which are important cell membrane components, have
critical roles in regulating cancer cell signaling to control pro-tumoral or antitumoral …

Background Inhibition of sphingosine kinase 1 (SphK1), which catalyzes bioactive lipid
sphingosine-1–phosphate (S1P), attenuates NLRP3 inflammasome activation. S1P exerts …

Lipid phosphate phosphatases (LPPs) are a group of three enzymes (LPP1–3) that belong
to a phospholipid phosphatase (PLPP) family. The LPPs dephosphorylate a wide spectrum …

Glioblastoma (GBM) is a primary malignant brain tumor with a dismal prognosis, partially
due to our inability to completely remove and kill all GBM cells. Rapid tumor recurrence …

Non-small cell lung cancer (NSCLC) accounts for 85~ 90% of lung cancer cases, with a poor
prognosis and a low 5-year survival rate. Sphingosine kinase-1 (SPHK1), a key enzyme in …

Purpose miR-451 is a tumor suppressive microRNA with several target genes, including
Macrophage migration inhibitory factor (MIF). As little is known about the expression and …