Ribosome biogenesis factors—from names to functions
K Dörner, C Ruggeri, I Zemp, U Kutay - The EMBO journal, 2023 - embopress.org
The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …
Breaking the chains: deubiquitylating enzyme specificity begets function
The deubiquitylating enzymes (DUBs, also known as deubiquitylases or deubiquitinases)
maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …
maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …
Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and oxidative stress response
NA Snyder, GM Silva - Journal of Biological Chemistry, 2021 - ASBMB
Ubiquitin signaling is a conserved, widespread, and dynamic process in which protein
substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability …
substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability …
Crosstalk between mammalian autophagy and the ubiquitin-proteasome system
NM Kocaturk, D Gozuacik - Frontiers in cell and developmental …, 2018 - frontiersin.org
Autophagy and the ubiquitin–proteasome system (UPS) are the two major intracellular
quality control and recycling mechanisms that are responsible for cellular homeostasis in …
quality control and recycling mechanisms that are responsible for cellular homeostasis in …
Disome and trisome profiling reveal genome-wide targets of ribosome quality control
S Meydan, NR Guydosh - Molecular cell, 2020 - cell.com
The ribosome-associated protein quality control (RQC) system that resolves stalled
translation events is activated when ribosomes collide and form disome, trisome, or higher …
translation events is activated when ribosomes collide and form disome, trisome, or higher …
Post-translational modifications of G Protein–Coupled receptors control cellular signaling dynamics in space and time
G protein–coupled receptors (GPCRs) are a large family comprising> 800 signaling
receptors that regulate numerous cellular and physiologic responses. GPCRs have been …
receptors that regulate numerous cellular and physiologic responses. GPCRs have been …
Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunction
P Bishop, D Rocca, JM Henley - Biochemical Journal, 2016 - portlandpress.com
Ubiquitin C-terminal hydrolase L1 (UCH-L1) is an extremely abundant protein in the brain
where, remarkably, it is estimated to make up 1–5% of total neuronal protein. Although it …
where, remarkably, it is estimated to make up 1–5% of total neuronal protein. Although it …
Advances in discovering deubiquitinating enzyme (DUB) inhibitors
NJ Schauer, RS Magin, X Liu, LM Doherty… - Journal of medicinal …, 2019 - ACS Publications
Deubiquitinating enzymes, or DUBs, comprise a family of proteases that regulate
ubiquitination dynamics. Since their discovery, genetic and functional studies have …
ubiquitination dynamics. Since their discovery, genetic and functional studies have …
Cellular functions and molecular mechanisms of non-lysine ubiquitination
AJ McClellan, SH Laugesen, L Ellgaard - Open Biology, 2019 - royalsocietypublishing.org
Protein ubiquitination is of great cellular importance through its central role in processes
such as degradation, DNA repair, endocytosis and inflammation. Canonical ubiquitination …
such as degradation, DNA repair, endocytosis and inflammation. Canonical ubiquitination …
Resolving the complexity of ubiquitin networks
Ubiquitination regulates nearly all cellular processes by coordinated activity of ubiquitin
writers (E1, E2, and E3 enzymes), erasers (deubiquitinating enzymes) and readers (proteins …
writers (E1, E2, and E3 enzymes), erasers (deubiquitinating enzymes) and readers (proteins …