The intracellular environment represents an extremely crowded milieu, with a limited amount
of free water and an almost complete lack of unoccupied space. Obviously, slightly salted …

Cell culturing, whether for tissue engineering or cell biology studies, always involves placing
cells in a non‐natural environment and no material currently exist that can mimic the entire …

In recent years, better instrumentation and greater computing power have enabled the
imaging of elusive biomolecule dynamics in cells, driving many advances in understanding …

It is now generally accepted that macromolecules do not act in isolation but “live” in a
crowded environment, that is, an environment populated by numerous different molecules …

In recent years significant effort has been devoted to exploring the potential effects of
macromolecular crowding on protein folding and association phenomena. Theoretical …

Most theories about macromolecular crowding focus on two ideas: the macromolecular
nature of the crowder and entropy. For proteins, the volume excluded by the crowder favors …

Chromosome replication depends on efficient removal of nucleosomes by accessory factors
to ensure rapid access to genomic information. Here, we show this process requires …

In vivo, the interior and exterior of cells is populated by various macromolecules that create
an extremely crowded milieu. Yet again, in vitro eukaryotic cell culture is conducted in dilute …

Recent experiments inside cells and in cytomimetic conditions have demonstrated that the
crowded environments found therein can significantly reshape the energy landscapes of …

This article provides a thorough overview of the available resorbable biomaterials
appropriate for producing replacements for damaged tissues. In addition, their various …