[HTML][HTML] What macromolecular crowding can do to a protein
IM Kuznetsova, KK Turoverov, VN Uversky - International journal of …, 2014 - mdpi.com
The intracellular environment represents an extremely crowded milieu, with a limited amount
of free water and an almost complete lack of unoccupied space. Obviously, slightly salted …
of free water and an almost complete lack of unoccupied space. Obviously, slightly salted …
25th anniversary article: designer hydrogels for cell cultures: a materials selection guide
Cell culturing, whether for tissue engineering or cell biology studies, always involves placing
cells in a non‐natural environment and no material currently exist that can mimic the entire …
cells in a non‐natural environment and no material currently exist that can mimic the entire …
Weak chemical interactions that drive protein evolution: crowding, sticking, and quinary structure in folding and function
D Guin, M Gruebele - Chemical reviews, 2019 - ACS Publications
In recent years, better instrumentation and greater computing power have enabled the
imaging of elusive biomolecule dynamics in cells, driving many advances in understanding …
imaging of elusive biomolecule dynamics in cells, driving many advances in understanding …
Molecular crowding: the history and development of a scientific paradigm
It is now generally accepted that macromolecules do not act in isolation but “live” in a
crowded environment, that is, an environment populated by numerous different molecules …
crowded environment, that is, an environment populated by numerous different molecules …
Models of macromolecular crowding effects and the need for quantitative comparisons with experiment
AH Elcock - Current opinion in structural biology, 2010 - Elsevier
In recent years significant effort has been devoted to exploring the potential effects of
macromolecular crowding on protein folding and association phenomena. Theoretical …
macromolecular crowding on protein folding and association phenomena. Theoretical …
Unexpected effects of macromolecular crowding on protein stability
LA Benton, AE Smith, GB Young, GJ Pielak - Biochemistry, 2012 - ACS Publications
Most theories about macromolecular crowding focus on two ideas: the macromolecular
nature of the crowder and entropy. For proteins, the volume excluded by the crowder favors …
nature of the crowder and entropy. For proteins, the volume excluded by the crowder favors …
The fork protection complex recruits FACT to reorganize nucleosomes during replication
Chromosome replication depends on efficient removal of nucleosomes by accessory factors
to ensure rapid access to genomic information. Here, we show this process requires …
to ensure rapid access to genomic information. Here, we show this process requires …
[HTML][HTML] It is time to crowd your cell culture media–physicochemical considerations with biological consequences
D Tsiapalis, DI Zeugolis - Biomaterials, 2021 - Elsevier
In vivo, the interior and exterior of cells is populated by various macromolecules that create
an extremely crowded milieu. Yet again, in vitro eukaryotic cell culture is conducted in dilute …
an extremely crowded milieu. Yet again, in vitro eukaryotic cell culture is conducted in dilute …
[HTML][HTML] Influence of crowded cellular environments on protein folding, binding, and oligomerization: biological consequences and potentials of atomistic modeling
HX Zhou - FEBS letters, 2013 - Elsevier
Recent experiments inside cells and in cytomimetic conditions have demonstrated that the
crowded environments found therein can significantly reshape the energy landscapes of …
crowded environments found therein can significantly reshape the energy landscapes of …
[HTML][HTML] Resorbable biomaterials used for 3D scaffolds in tissue engineering: A review
S Vach Agocsova, M Culenova, I Birova, L Omanikova… - Materials, 2023 - mdpi.com
This article provides a thorough overview of the available resorbable biomaterials
appropriate for producing replacements for damaged tissues. In addition, their various …
appropriate for producing replacements for damaged tissues. In addition, their various …