The concept of a prion as an infectious self-propagating protein isoform was initially
proposed to explain certain mammalian diseases. It is now clear that yeast also has …

SUMMARY A prion is an infectious protein horizontally transmitting a disease or trait without
a required nucleic acid. Yeast and fungal prions are nonchromosomal genes composed of …

Bacteria, fungi, protozoa, chromista and plants all harbor homologues of Hsp104, a AAA+
ATPase that collaborates with Hsp70 and Hsp40 to promote protein disaggregation and …

Hsp70 molecular chaperones play a variety of functions in every organism, cell type and
organelle, and their activities have been implicated in a number of human pathologies …

Protein aggregation is intimately associated with cellular stress and is accelerated during
aging, disease, and cellular dysfunction. Yeast cells rely on the ATP-consuming chaperone …

The [PSI+] prion is the aggregated self-propagating form of the Sup35 protein from the yeast
Saccharomyces cerevisiae. Aggregates of Sup35 in [PSI+] cells exist in different heritable …

Prions are alternatively folded, self-perpetuating protein isoforms involved in a variety of
biological and pathological processes. Yeast prions are protein-based heritable elements …

The molecular chaperone 70-kDa heat-shock proteins (Hsp70s) play essential roles in
maintaining protein homeostasis. Hsp110, an Hsp70 homolog, is highly efficient in …

Hsp100 family chaperones of microorganisms and plants cooperate with the
Hsp70/Hsp40/NEF system to resolubilize and reactivate stress-denatured proteins. In yeast …

Proteins of the Hsp110 family are molecular chaperones that play important roles in protein
homeostasis in eukaryotes. The pathogenic fungus Candida albicans, which causes …