Phosphoinositides: tiny lipids with giant impact on cell regulation

T Balla - Physiological reviews, 2013 - journals.physiology.org
Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Structural basis for regulation of phosphoinositide kinases and their involvement in human disease

JE Burke - Molecular cell, 2018 - cell.com
Lipid phosphoinositides play fundamental roles in virtually all pathways that control a cell's
decision to grow, move, divide, and die. Because of this, kinases that phosphorylate …

A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi

GRV Hammond, MP Machner, T Balla - Journal of Cell Biology, 2014 - rupress.org
Polyphosphoinositides are an important class of lipid that recruit specific effector proteins to
organelle membranes. One member, phosphatidylinositol 4-phosphate (PtdIns4 P) has …

Targeting Plasmodium PI(4)K to eliminate malaria

CW McNamara, MCS Lee, CS Lim, SH Lim, J Roland… - Nature, 2013 - nature.com
Achieving the goal of malaria elimination will depend on targeting Plasmodium pathways
essential across all life stages. Here we identify a lipid kinase, phosphatidylinositol-4-OH …

Cytokinesis in animal cells

PP D'Avino, MG Giansanti… - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
Cell division ends with the physical separation of the two daughter cells, a process known as
cytokinesis. This final event ensures that nuclear and cytoplasmic contents are accurately …

Rab GTPases and membrane identity: causal or inconsequential?

FA Barr - Journal of Cell Biology, 2013 - rupress.org
Rab GTPases are highly conserved components of vesicle trafficking pathways that help to
ensure the fusion of a vesicle with a specific target organelle membrane. Specific regulatory …

Rab GTPases and their interacting protein partners: Structural insights into Rab functional diversity

O Pylypenko, H Hammich, IM Yu, A Houdusse - Small GTPases, 2018 - Taylor & Francis
Rab molecular switches are key players in defining membrane identity and regulating
intracellular trafficking events in eukaryotic cells. In spite of their global structural similarity …

Molecular regulation of lumen morphogenesis

A Datta, DM Bryant, KE Mostov - Current Biology, 2011 - cell.com
The asymmetric polarization of cells allows specialized functions to be performed at discrete
subcellular locales. Spatiotemporal coordination of polarization between groups of cells …

Surveillance-activated defenses block the ROS–induced mitochondrial unfolded protein response

ED Runkel, S Liu, R Baumeister, E Schulze - PLoS genetics, 2013 - journals.plos.org
Disturbance of cellular functions results in the activation of stress-signaling pathways that
aim at restoring homeostasis. We performed a genome-wide screen to identify components …

Coordination between RAB GTPase and phosphoinositide regulation and functions

S Jean, AA Kiger - Nature reviews Molecular cell biology, 2012 - nature.com
Membrane trafficking relies on dynamic changes in membrane identities that are determined
by the regulation of distinct RAB GTPases and phosphoinositides. RABs and …