Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Lipid phosphoinositides play fundamental roles in virtually all pathways that control a cell's
decision to grow, move, divide, and die. Because of this, kinases that phosphorylate …

Polyphosphoinositides are an important class of lipid that recruit specific effector proteins to
organelle membranes. One member, phosphatidylinositol 4-phosphate (PtdIns4 P) has …

Achieving the goal of malaria elimination will depend on targeting Plasmodium pathways
essential across all life stages. Here we identify a lipid kinase, phosphatidylinositol-4-OH …

Cell division ends with the physical separation of the two daughter cells, a process known as
cytokinesis. This final event ensures that nuclear and cytoplasmic contents are accurately …

Rab GTPases are highly conserved components of vesicle trafficking pathways that help to
ensure the fusion of a vesicle with a specific target organelle membrane. Specific regulatory …

Rab molecular switches are key players in defining membrane identity and regulating
intracellular trafficking events in eukaryotic cells. In spite of their global structural similarity …

The asymmetric polarization of cells allows specialized functions to be performed at discrete
subcellular locales. Spatiotemporal coordination of polarization between groups of cells …

Disturbance of cellular functions results in the activation of stress-signaling pathways that
aim at restoring homeostasis. We performed a genome-wide screen to identify components …

Membrane trafficking relies on dynamic changes in membrane identities that are determined
by the regulation of distinct RAB GTPases and phosphoinositides. RABs and …