The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are voltage-gated
ion channels that critically modulate neuronal activity. Four HCN subunits (HCN1–4) have …

Cyclic nucleotide-binding domain (CNBD) channels are a family of ion channels in the
voltage-gated K+ channel superfamily that play crucial roles in many physiological …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels underlie the control of
rhythmic activity in cardiac and neuronal pacemaker cells. In HCN, the polarity of voltage …

Recently, there have been remarkable improvements in pulsed ESR sensitivity, paving the
way for broader applicability of ESR in the measurement of biological distance constraints …

Hyperpolarization-activated, cyclic nucleotide-sensitive (HCN) channels are key regulators
of subthreshold membrane potentials in excitable cells. The four mammalian HCN channel …

The recent introduction of shaped pulses to Double Electron Electron Resonance (DEER)
spectroscopy has led to significant enhancements in sensitivity through increased excitation …

Sensitive in-cell distance measurements in proteins using pulsed-electron spin resonance
(ESR) require reduction-resistant and cleavage-resistant spin labels. Among the reduction …

Abstract Double Electron-Electron Resonance (DEER) spectroscopy is a solid-state pulse
Electron Paramagnetic Resonance (EPR) experiment that measures distances between …

We adapt a new wavelet-transform-based method of denoising experimental signals to
pulse-dipolar electron-spin resonance spectroscopy (PDS). We show that signal averaging …

Binding of TRIP8b to the cyclic nucleotide binding domain (CNBD) of mammalian
hyperpolarization-activated cyclic nucleotide-gated (HCN) channels prevents their …