Interaction of norsecurinine-type monomeric and dimeric alkaloids with α-tubulin: A molecular docking study

G Vergoten, C Bailly - Exploration of Drug Science, 2024 - explorationpub.com
Aim: New microtubule-targeting agents are needed to improve cancer treatment. The recent
characterization of the anticancer alkaloid securinine as a tubulin-binding agent prompted …

Design, Synthesis, and Evaluation of An Anti‐trypanosomal [1, 2, 4] Triazolo [1, 5‐a] pyrimidine Probe for Photoaffinity Labeling Studies.

B Lucero, KR Francisco, C Varricchio, LJ Liu… - …, 2024 - Wiley Online Library
Studies have shown that depending on the substitution pattern, microtubule (MT)‐targeting
1, 2, 4‐triazolo [1, 5‐a] pyrimidines (TPDs) can produce different cellular responses in …