BACKGROUND: The American Heart Association (AHA), in conjunction with the National
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …

Despite major advancements in cardiovascular medicine, sudden cardiac death (SCD)
continues to be an enormous medical and societal challenge, claiming millions of lives …

Background Invasive mechanical ventilation in critically ill adults involves adjusting the
fraction of inspired oxygen to maintain arterial oxygen saturation. The oxygen-saturation …

Background Guidelines recommend normocapnia for adults with coma who are resuscitated
after out-of-hospital cardiac arrest. However, mild hypercapnia increases cerebral blood flow …

Background Evidence to support the choice of blood-pressure targets for the treatment of
comatose survivors of out-of-hospital cardiac arrest who are receiving intensive care is …

Background Guidelines recommend active fever prevention for 72 hours after cardiac arrest.
Data from randomized clinical trials of this intervention have been lacking. Methods We …

Cardiac arrest is an important public health issue, with a survival rate of approximately 15 to
22%. A great proportion of these deaths occur after resuscitation due to post-cardiac arrest …

Rationale: Supplemental oxygen is widely administered to ICU patients, but appropriate
oxygenation targets remain unclear. Objectives: This study aimed to determine whether a …

Importance Among critically ill adults, randomized trials have not found oxygenation targets
to affect outcomes overall. Whether the effects of oxygenation targets differ based on an …

The cerebral oxygen cascade includes three key stages:(a) convective oxygen delivery
representing the bulk flow of oxygen to the cerebral vascular bed;(b) diffusion of oxygen from …