Significance: Skin scarring poses a major biomedical burden for hundreds of millions of
patients annually. However, this burden could be mitigated by therapies that promote wound …

Objective: The wound healing response may be viewed as partially overlapping sets of two
physiological processes, regeneration and wound repair with the former overrepresented in …

In adult mammals, skin wounds typically heal by scarring rather than through regeneration.
In contrast," super-healer" Murphy Roths Large (MRL) mice have the unusual ability to …

Objective Emerging evidence suggests that genetic components contribute significantly to
cartilage degeneration in osteoarthritis pathophysiology, but little information is available on …

Background The laboratory mouse is the most commonly used model for studying variation
in complex traits relevant to human disease. Here we present the whole-genome sequences …

Among other cells, macrophages regulate the inflammatory and reparative phases during
wound healing but genetic determinants and detailed molecular pathways that modulate …

Regenerative medicine aims to restore normal tissue architecture and function. However,
the basis of tissue regeneration in mammalian solid organs remains undefined. Remarkably …

Anterior chamber depth (ACD) is a quantitative trait associated with primary angle closure
glaucoma (PACG). Although ACD is highly heritable, known genetic variations explain a …

Most of the studies on cutaneous wound healing are focused on epidermal closure. This is
obviously important, as the epidermis constitutes the main barrier that separates the inner …

External ear hole closure in LG/J mice represents a model of regenerative response. It is
accompanied by the formation of a blastema-like structure and the re-growth of multiple …