Summary Three-dimensional (3D) chromatin organization maps help dissect cell-type-
specific gene regulatory programs. Furthermore, 3D chromatin maps contribute to …

Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) to produce phosphatidic
acid (PA). Mammalian DGK comprises ten isozymes (α–κ) and regulates a wide variety of …

The diacylglycerol kinase family, which can attenuate diacylglycerol signaling and activate
phosphatidic acid signaling, regulates various signaling transductions in the mammalian …

Increased levels of the second messenger lipid diacylglycerol (DAG) induce downstream
signaling events including the translocation of C1-domain-containing proteins toward the …

Diacylglycerol kinase (DGK) consists of 10 isozymes. The α-isozyme enhances the
proliferation of cancer cells. However, DGKα facilitates the nonresponsive state of immunity …

Diacylglycerol kinase (DGK) is a lipid kinase converting diacylglycerol to phosphatidic acid,
and regulates many enzymes including protein kinase C, phosphatidylinositol 4-phosphate …

The drastic increase in the number of patients with diabetes and its complications is a global
issue. Diabetic nephropathy, the leading cause of chronic kidney disease, significantly …

β-Cell swelling induces membrane depolarization, which has been suggested to be caused
at least partly by the activation of cation channels. Here, we show the identification of the …

Diabetic nephropathy (DN) is one of vascular complications of diabetes and is caused by
abnormal protein kinase C activation as a result of increased diacylglycerol (DG) production …

Diacylglycerol (DAG) is a lipid signal messenger and plays a physiological role in β-cells.
Since defective glucose homeostasis increases de novo DAG synthesis, DAG may also …