Over the past decade, we have witnessed a flourishing of novel strategies to enhance
neuroplasticity and promote axon regeneration following spinal cord injury, and results from …

Neurodegenerative disorders like Parkinson's disease, Alzheimer's disease, or amyotrophic
lateral sclerosis are affecting a rapidly increasing population worldwide. While common …

Chondroitinase ABC (ChABC) in combination with rehabilitation has been shown to promote
functional recovery in acute spinal cord injury. For clinical use, the optimal treatment window …

Inhibitory molecules derived from CNS myelin and glial scar tissue are major causes for
insufficient functional regeneration in the mammalian CNS. A multitude of these molecules …

Purpose.: To investigate the effect of K-115, a novel Rho kinase (ROCK) inhibitor, on retinal
ganglion cell (RGC) survival in an optic nerve crush (NC) model. Additionally, to determine …

Ras homolog (Rho)-associated kinases (ROCKs) belong to the serine-threonine kinase
family, which plays a pivotal role in regulating the damage, survival, axon guidance, and …

After a CNS injury in the adult mammals, axonal regeneration is very limited because of the
reduced intrinsic growth capacity and nonpermissive environment for axonal elongation …

Background Spinal cord injury (SCI) is a devastating event often resulting in permanent
neurologic deficit. Research has revealed an understanding of mechanisms that occur after …

Three theories of regeneration dominate neuroscience today, all purporting to explain why
the adult central nervous system (CNS) cannot regenerate. One theory proposes that Nogo …

An increasing number of therapies for spinal cord injury (SCI) are emerging from the
laboratory and seeking translation into human clinical trials. Many of these are administered …