The presence of a patent foramen ovale (PFO) is implicated in the pathogenesis of a number
of medical conditions; however, the subject remains controversial and no official statements …

Cardiac embolism accounts for an increasing proportion of ischemic strokes and might
multiply several-fold during the next decades. However, research points to several potential …

Background Trials of patent foramen ovale (PFO) closure to prevent recurrent stroke have
been inconclusive. We investigated whether patients with cryptogenic stroke and …

Background: Recent reports showing the favorable role of patent foramen ovale (PFO)
closure in patients with cryptogenic stroke have raised the issue of selecting optimal …

Key Clinical Points Cryptogenic Stroke One quarter of patients with ischemic stroke have no
probable cause found after standard workup, including echocardiography, inpatient cardiac …

Importance Recent epidemiologic and therapeutic advances have transformed
understanding of the role of and therapeutic approach to patent foramen ovale (PFO) in …

Nearly one-half of patients with cryptogenic stroke have a patent foramen ovale (PFO). The
dilemma of whether to close these PFOs percutaneously, in an effort to reduce the risk of …

Background Patent foramen ovale (PFO) is a contributor to embolic stroke of undetermined
source (ESUS). Subgroup analyses from previous studies suggest that anticoagulation …

Background: Cryptogenic stroke accounts for 30% to 40% of ischemic stroke. It is essential
to determine the possible culprit because this will improve secondary stroke prevention …

Background The comparative effectiveness of percutaneous closure of patent foramen ovale
(PFO) plus medical therapy versus medical therapy alone for cryptogenic stroke is uncertain …