Cl− channels reside both in the plasma membrane and in intracellular organelles. Their
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …

Endothelial cells (EC) form a unique signal-transducing surface in the vascular system. The
abundance of ion channels in the plasma membrane of these nonexcitable cells has raised …

Abstract Calcium (Ca2+)-activated chloride channels are fundamental mediators in
numerous physiological processes including transepithelial secretion, cardiac and neuronal …

Calcium-dependent chloride channels are required for normal electrolyte and fluid
secretion, olfactory perception, and neuronal and smooth muscle excitability. The molecular …

Calcium-activated chloride channels (CaCCs) are major regulators of sensory transduction,
epithelial secretion, and smooth muscle contraction. Other crucial roles of CaCCs include …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

▪ Abstract Calcium-activated chloride channels (CaCCs) play important roles in cellular
physiology, including epithelial secretion of electrolytes and water, sensory transduction …

Abstract Ca 2+-activated Cl− channels (CaCCs) are a class of Cl− channels activated by
intracellular Ca 2+ that are known to mediate numerous physiological functions. In 2008, the …

Aim: This review describes molecular and functional properties of the following Cl–channels:
the ClC family of voltage‐dependent Cl–channels, the cAMP‐activated transmembrane …

Interstitial cells of Cajal (ICC) are unique cells that generate electrical pacemaker activity in
gastrointestinal (GI) muscles. Many previous studies have attempted to characterize the …