Resting naive CD8+ T cells have an astounding capacity to react to pathogens by massive
expansion and differentiation into cytotoxic effector cells that migrate to all corners of the …

Toxoplasma gondii is a protozoan parasite of medical and veterinary significance that is
able to infect any warm-blooded vertebrate host. In addition to its importance to public …

Neutrophils are the primary cell type involved in lung ischemia-reperfusion injury (IRI), which
remains a frequent and morbid complication after organ transplantation. Endogenous lipid …

The generation of tumor-directed cytotoxic T lymphocytes is considered crucial for the
induction of antitumor immunity. To activate these CD8+ T cells, antigen-presenting cells …

Adoptive cell transfer (ACT) of purified naive, stem cell memory, and central memory T cell
subsets results in superior persistence and antitumor immunity compared with ACT of …

To mount an immune response, lymphocytes must recirculate between the blood and lymph
nodes, recognize antigens upon contact with specialized presenting cells, proliferate to …

Despite the immense public health successes of immunization over the past century,
effective vaccines are still lacking for globally important pathogens such as human …

An important function of the blood–brain barrier is to exclude pathogens from the central
nervous system, but some microorganisms benefit from the ability to enter this site. It has …

Lymph node (LN) macrophages have long been known for their efficient uptake of lymph-
borne antigens. A convergence of studies on innate and adaptive immune responses has …

Defining where and in what form lymphocytes encounter antigen is fundamental to
understanding how immune responses occur. Although knowledge of the recognition of …