[HTML][HTML] CD8+ T cells: foot soldiers of the immune system
N Zhang, MJ Bevan - Immunity, 2011 - cell.com
Resting naive CD8+ T cells have an astounding capacity to react to pathogens by massive
expansion and differentiation into cytotoxic effector cells that migrate to all corners of the …
expansion and differentiation into cytotoxic effector cells that migrate to all corners of the …
Immune response and immunopathology during toxoplasmosis
Toxoplasma gondii is a protozoan parasite of medical and veterinary significance that is
able to infect any warm-blooded vertebrate host. In addition to its importance to public …
able to infect any warm-blooded vertebrate host. In addition to its importance to public …
Resolvin D1 prevents injurious neutrophil swarming in transplanted lungs
W Li, HM Shepherd, Y Terada… - Proceedings of the …, 2023 - National Acad Sciences
Neutrophils are the primary cell type involved in lung ischemia-reperfusion injury (IRI), which
remains a frequent and morbid complication after organ transplantation. Endogenous lipid …
remains a frequent and morbid complication after organ transplantation. Endogenous lipid …
[HTML][HTML] CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens
K Asano, A Nabeyama, Y Miyake, CH Qiu, A Kurita… - Immunity, 2011 - cell.com
The generation of tumor-directed cytotoxic T lymphocytes is considered crucial for the
induction of antitumor immunity. To activate these CD8+ T cells, antigen-presenting cells …
induction of antitumor immunity. To activate these CD8+ T cells, antigen-presenting cells …
[HTML][HTML] Memory T cell–driven differentiation of naive cells impairs adoptive immunotherapy
CA Klebanoff, CD Scott, AJ Leonardi… - The Journal of …, 2016 - Am Soc Clin Investig
Adoptive cell transfer (ACT) of purified naive, stem cell memory, and central memory T cell
subsets results in superior persistence and antitumor immunity compared with ACT of …
subsets results in superior persistence and antitumor immunity compared with ACT of …
A decade of imaging cellular motility and interaction dynamics in the immune system
RN Germain, EA Robey, MD Cahalan - Science, 2012 - science.org
To mount an immune response, lymphocytes must recirculate between the blood and lymph
nodes, recognize antigens upon contact with specialized presenting cells, proliferate to …
nodes, recognize antigens upon contact with specialized presenting cells, proliferate to …
Immunological principles guiding the rational design of particles for vaccine delivery
Despite the immense public health successes of immunization over the past century,
effective vaccines are still lacking for globally important pathogens such as human …
effective vaccines are still lacking for globally important pathogens such as human …
Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous system
C Konradt, N Ueno, DA Christian, JH Delong… - Nature …, 2016 - nature.com
An important function of the blood–brain barrier is to exclude pathogens from the central
nervous system, but some microorganisms benefit from the ability to enter this site. It has …
nervous system, but some microorganisms benefit from the ability to enter this site. It has …
Lymph node macrophages
EE Gray, JG Cyster - Journal of innate immunity, 2012 - karger.com
Lymph node (LN) macrophages have long been known for their efficient uptake of lymph-
borne antigens. A convergence of studies on innate and adaptive immune responses has …
borne antigens. A convergence of studies on innate and adaptive immune responses has …
[HTML][HTML] B cell follicles and antigen encounters of the third kind
JG Cyster - Nature immunology, 2010 - nature.com
Defining where and in what form lymphocytes encounter antigen is fundamental to
understanding how immune responses occur. Although knowledge of the recognition of …
understanding how immune responses occur. Although knowledge of the recognition of …