The known seven mammalian receptor subunits (P2X1–7) form cationic channels gated by
ATP. Three subunits compose a receptor channel. Each subunit is a polypeptide consisting …

Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …

P2X receptors are trimeric, non-selective cation channels activated by ATP that have
important roles in the cardiovascular, neuronal and immune systems. Despite their central …

The 28 mammalian members of the super-family of transient receptor potential (TRP)
channels are cation channels, mostly permeable to both monovalent and divalent cations …

Extracellular adenosine 5′ triphosphate (ATP) is a widespread cell-to-cell signaling
molecule in the brain, where it activates cell surface P2X and P2Y receptors. P2X receptors …

Extracellular adenosine 5′-triphosphate (ATP) activates cell surface P2X and P2Y
receptors. P2X receptors are membrane ion channels preferably permeable to sodium …

P2X receptors are membrane ion channels activated by the binding of extracellular
adenosine triphosphate (ATP). For years their functional significance was consigned to …

P2X receptors are membrane cation channels gated by extracellular ATP. Seven P2X
receptor subunits (P2X1-7) are widely distributed in excitable and nonexcitable cells of …

Chronic pain is a highly prevalent debilitating condition for which treatment options remain
limited for many patients. Ionotropic ATP signalling through excitatory and calcium …

Secondary injury exacerbates the extent of spinal cord insults, yet the mechanistic basis of
this phenomenon has largely been unexplored. Here we report that broad regions of the …