Systemic lupus erythematosus (SLE) is a disease characterized by dysregulation and
hyperreactivity of the immune response at various levels, including hyperactivation of …

The adult kidney hosts tissue-resident macrophages that can cause, prevent, and/or repair
renal damage. Most of these macrophages derive from embryonic progenitors that colonize …

Inflammation is an important component of fibrosis but immune processes that orchestrate
kidney fibrosis are not well understood. Here we apply single-cell sequencing to a mouse …

Development of localized inflammatory environments by M1 macrophages in the cardiac
infarction region exacerbates heart failure after myocardial infarction (MI). Therefore, the …

Acute lung injury (ALI) is a common and devastating clinical disorder featured by excessive
inflammatory responses. Stimulator of interferon genes (STING) is an indispensable …

Mixed lineage kinase 3 (MLK3) deficiency reduces macrophage‐associated inflammation in
a murine model of nonalcoholic steatohepatitis (NASH). However, the mechanistic links …

IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide and
defined by the presence of IgA-containing immune complexes in the mesangium that induce …

Background Chemokine signalling is required for the homing of leukocytes during retinal
inflammation, and is associated with pathogenesis of diseases such as age-related macular …

Inflammatory monocytes can be manipulated by environmental cues to perform multiple
functions. To define the role of monocytes during primary or secondary infection with an intra …

Monocytes/macrophages are important in orchestrating inflammatory responses. However,
knowledge of the long noncoding RNA (lncRNA) regulation of monocytic cell differentiation …