Nucleic acids and their analogues for biomedical applications

F Wang, P Li, HC Chu, PK Lo - Biosensors, 2022 - mdpi.com
Nucleic acids are emerging as powerful and functional biomaterials due to their molecular
recognition ability, programmability, and ease of synthesis and chemical modification …

Clinical advances of RNA therapeutics for treatment of neurological and neuromuscular diseases

A Holm, SN Hansen, H Klitgaard, S Kauppinen - RNA biology, 2022 - Taylor & Francis
ABSTRACT RNA therapeutics comprise a diverse group of oligonucleotide-based drugs
such as antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and short …

Getting drugs to the brain: advances and prospects of organic nanoparticle delivery systems for assisting drugs to cross the blood–brain barrier

Q Tan, S Zhao, T Xu, Q Wang, M Lan, L Yan… - Journal of materials …, 2022 - pubs.rsc.org
The blood–brain barrier (BBB) plays an irreplaceable role in protecting the central nervous
system (CNS) from bloodborne pathogens. However, the BBB complicates the treatment of …

New drug delivery systems developed for brain targeting

SU Rawal, BM Patel, MM Patel - Drugs, 2022 - Springer
The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSF) are two of
the most complex and sophisticated concierges that defend the central nervous system …

An up-to-date review of natural nanoparticles for cancer management

D Ion, AG Niculescu, DN Păduraru, O Andronic… - Pharmaceutics, 2021 - mdpi.com
Cancer represents one of the leading causes of morbidity and mortality worldwide, imposing
an urgent need to develop more efficient treatment alternatives. In this respect, much …

A stable DNA Tetrahedra–AuNCs nanohybrid: On-site programmed disassembly for tumor imaging and combination therapy

H Sun, T Wang, W Ma, J Huang, B Chen, H Cheng… - Biomaterials, 2022 - Elsevier
Despite DNA nanotechnology has spawned a broad variety and taken a giant leap toward
cancer theranostic applications over the last decade, the homogeneous DNA nanostructures …

The applications of functionalized DNA nanostructures in bioimaging and cancer therapy

Y Zeng, RL Nixon, W Liu, R Wang - Biomaterials, 2021 - Elsevier
Deoxyribonucleic acid (DNA) is a molecular carrier of genetic information that can be
fabricated into functional nanomaterials in biochemistry and engineering fields. Those DNA …

Nucleic acid nanostructures for in vivo applications: The influence of morphology on biological fate

NI Langlois, KY Ma, HA Clark - Applied Physics Reviews, 2023 - pubs.aip.org
The development of programmable biomaterials for use in nanofabrication represents a
major advance for the future of biomedicine and diagnostics. Recent advances in structural …

“Targeting design” of nanoparticles in tumor therapy

T Yang, J Zhai, D Hu, R Yang, G Wang, Y Li, G Liang - Pharmaceutics, 2022 - mdpi.com
Tumor-targeted therapy based on nanoparticles is a popular research direction in the
biomedical field. After decades of research and development, both the passive targeting …

[HTML][HTML] Trends in Nanotechnology to improve therapeutic efficacy across special structures

MI Khan, F Batool, F Kalsoom, S Gao, R Ali, W Wang… - OpenNano, 2022 - Elsevier
Cancer is among the leading causes of death worldwide. Its treatment has become a
horrible dream for researchers. Although different approaches have been used to treat …