Increased glucose metabolism and uptake are characteristic of many tumors and used
clinically to diagnose and monitor cancer progression. In addition to cancer cells, the tumor …

Metabolism of cancer cells is geared toward biomass production and proliferation. Since the
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …

Tissues derive ATP from two pathways—glycolysis and the tricarboxylic acid (TCA) cycle
coupled to the electron transport chain. Most energy in mammals is produced via TCA …

The uptake and metabolism of nutrients support fundamental cellular process from
bioenergetics to biomass production and cell fate regulation. While many studies of cell …

Tumour initiation and progression requires the metabolic reprogramming of cancer cells.
Cancer cells autonomously alter their flux through various metabolic pathways in order to …

Recently, in the field of cancer treatment, the paradigm has changed to immunotherapy that
activates the immune system to induce cancer attacks. Among them, immune checkpoint …

Cancer has myriad effects on metabolism that include both rewiring of intracellular
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …

Most (if not all) tumors emerge and progress under a strong evolutionary pressure imposed
by trophic, metabolic, immunological, and therapeutic factors. The relative impact of these …

Metastasis formation is the major cause of death in most patients with cancer. Despite
extensive research, targeting metastatic seeding and colonization is still an unresolved …

Several non-redundant features of the tumour microenvironment facilitate
immunosuppression and limit anticancer immune responses. These include physical …