Anti-cancer nitrogen-containing heterocyclic compounds

Z Hosseinzadeh, A Ramazani… - Current Organic …, 2018 - benthamdirect.com
Cancer is one of the leading causes of death worldwide. Mutation of the cell regulates genes
and protein causing cancer. Surgery, radiotherapy, and the use of anticancer agents are the …

[HTML][HTML] Microwave assisted reactions of azaheterocycles formedicinal chemistry applications

D Amariucai-Mantu, V Mangalagiu, R Danac… - Molecules, 2020 - mdpi.com
Microwave (MW) assisted reactions have became a powerful tool in azaheterocycles
chemistry during the last decades. Five and six membered ring azaheterocycles are …

[HTML][HTML] Benzoquinoline derivatives: an attractive approach to newly small molecules with anticancer activity

L Oniciuc, D Amăriucăi-Mantu, D Diaconu… - International Journal of …, 2023 - mdpi.com
This study presents the synthesis, structural characterization, and in vitro evaluation of
anticancer activity of some newly benzo [f] quinoline derivatives. The synthesis is facile and …

New indolizines with phenanthroline skeleton: Synthesis, structure, antimycobacterial and anticancer evaluation

R Danac, CM Al Matarneh, S Shova, T Daniloaia… - Bioorganic & Medicinal …, 2015 - Elsevier
We report herein a feasible study concerning the design, synthesis, structure and in vitro
antimycobacterial and anticancer activity of two new classes (containing four and five fused …

Synthesis, molecular modelling and anticancer evaluation of new pyrrolo[1,2-b]pyridazine and pyrrolo[2,1-a]phthalazine derivatives

L Popovici, RM Amarandi, II Mangalagiu… - Journal of enzyme …, 2019 - Taylor & Francis
Two new series of heterocyclic derivatives with potential anticancer activity, in which a
pyrrolo [1, 2-b] pyridazine or a pyrrolo [2, 1-a] phthalazine moiety was introduced in place of …

Synthesis, structure, antimycobacterial and anticancer evaluation of new pyrrolo-phenanthroline derivatives

CM Al Matarneh, II Mangalagiu, S Shova… - Journal of enzyme …, 2016 - Taylor & Francis
A study concerning design, synthesis, structure and in vitro antimycobacterial and anticancer
evaluation of new fused derivatives with pyrrolo [2, 1-c][4, 7] phenanthroline skeleton is …

[HTML][HTML] [3+ n] cycloaddition reactions: a milestone approach for elaborating pyridazine of potential interest in medicinal chemistry and optoelectronics

D Amariucai-Mantu, V Mangalagiu, II Mangalagiu - Molecules, 2021 - mdpi.com
During the last few decades, pyridazine derivatives have emerged as privileged structures in
heterocyclic chemistry, both because of their excellent chemistry and because of their …

[PDF][PDF] Microwave assisted synthesis of six member ring azaheterocycles and their antimycobacterial and anticancer evaluation

C Al Matarneh, CI Ciobanu, V Mangalagiu… - Rev …, 2020 - revistadechimie.ro
We report herein a comparative study concerning the influence of microwave (MW)
irradiation comparative with conventional thermal heating (TH) in the reaction of six member …

Hybrid anticancer 1, 2-diazine derivatives with multiple mechanism of action. Part 3 [4, 5]

V Antoci, D Mantu, DG Cozma, C Usru… - Medical Hypotheses, 2014 - Elsevier
Antitumour chemotherapy is nowadays a very active field of research, DNA targeting drugs
being the most widely used group in therapy. The design, synthesis and anticancer activity …

New hopes in cancer battle-a review of new molecules and treatment strategies

M Turek, M Krzyczmonik, P Balczewski - Medicinal Chemistry, 2016 - ingentaconnect.com
Background: Cancer is one of the most serious illnesses of our civilization. Therefore,
scientists of different disciplines try to find new treatment strategies and new chemical …