[HTML][HTML] Nanoscopy for endosomal escape quantification
The successful cytosolic delivery of nanoparticles is hampered by their endosomal
entrapment and degradation. To push forward the smart development of nanoparticles we …
entrapment and degradation. To push forward the smart development of nanoparticles we …
[HTML][HTML] Mechanisms of formation, structure, and dynamics of lipoprotein discs stabilized by amphiphilic copolymers: A comprehensive review
PS Orekhov, ME Bozdaganyan, N Voskoboynikova… - Nanomaterials, 2022 - mdpi.com
Amphiphilic copolymers consisting of alternating hydrophilic and hydrophobic units account
for a major recent methodical breakthrough in the investigations of membrane proteins …
for a major recent methodical breakthrough in the investigations of membrane proteins …
Cryo-EM structures of Escherichia coli cytochrome bo3 reveal bound phospholipids and ubiquinone-8 in a dynamic substrate binding site
Two independent structures of the proton-pumping, respiratory cytochrome bo 3 ubiquinol
oxidase (cyt bo 3) have been determined by cryogenic electron microscopy (cryo-EM) in …
oxidase (cyt bo 3) have been determined by cryogenic electron microscopy (cryo-EM) in …
[HTML][HTML] Lipid nanodiscs via ordered copolymers
Amphiphilic copolymers capable of extracting membrane proteins directly from lipid bilayers
into" native nanodiscs" promise a simpler membrane protein sample preparation procedure …
into" native nanodiscs" promise a simpler membrane protein sample preparation procedure …
[HTML][HTML] Insights into lipid-protein interactions from computer simulations
Lipid-protein interactions play an important direct role in the function of many membrane
proteins. We argue they are key players in membrane structure, modulate membrane …
proteins. We argue they are key players in membrane structure, modulate membrane …
High Resolution Membrane Structures within Hybrid Lipid‐Polymer Vesicles Revealed by Combining X‐Ray Scattering and Electron Microscopy
R Seneviratne, G Coates, Z Xu, CE Cornell… - Small, 2023 - Wiley Online Library
Hybrid vesicles consisting of phospholipids and block‐copolymers are increasingly finding
applications in science and technology. Herein, small angle X‐ray scattering (SAXS) and …
applications in science and technology. Herein, small angle X‐ray scattering (SAXS) and …
Emerging frontiers in virtual drug discovery: From quantum mechanical methods to deep learning approaches
Virtual screening-based approaches to discover initial hit and lead compounds have the
potential to reduce both the cost and time of early drug discovery stages, as well as to find …
potential to reduce both the cost and time of early drug discovery stages, as well as to find …
Polymer nanodiscs and their bioanalytical potential
Membrane proteins (MPs) play a pivotal role in cellular function and are therefore
predominant pharmaceutical targets. Although detailed understanding of MP structure and …
predominant pharmaceutical targets. Although detailed understanding of MP structure and …
Measurement of residual dipolar couplings using magnetically aligned and flipped nanodiscs
T Ravula, A Ramamoorthy - Langmuir, 2021 - ACS Publications
Recent developments in lipid nanodisc technology have successfully overcome the major
challenges in the structural and functional studies of membrane proteins and drug delivery …
challenges in the structural and functional studies of membrane proteins and drug delivery …
[HTML][HTML] Hydrogen-deuterium exchange mass-spectrometry of secondary active transporters: from structural dynamics to molecular mechanisms
M Giladi, D Khananshvili - Frontiers in Pharmacology, 2020 - frontiersin.org
Membrane transporters allow the selective transport of otherwise poorly permeable solutes
across the cell membrane and thus, play a key role in maintaining cellular homeostasis in all …
across the cell membrane and thus, play a key role in maintaining cellular homeostasis in all …