Toxigenic fungi and mycotoxins entered human food supplies about the time when mankind
first began to cultivate crops and to store them from one season to the next, perhaps 10,000 …

This review constitutes an overview of our investigations of aristolochic acid nephropathy, a
chronic kidney disease associated with carcinomas of the upper urinary tract. Our studies …

Aristolochic acid, a potent human carcinogen produced by Aristolochia plants, is associated
with urothelial carcinoma of the upper urinary tract (UUC). Following metabolic activation …

Current non-invasive approaches for detection of urothelial cancers are suboptimal. We
developed a test to detect urothelial neoplasms using DNA recovered from cells shed into …

Endemic (Balkan) nephropathy is a chronic tubulointerstitial disease frequently
accompanied by urothelial cell carcinomas of the upper urinary tract. This disorder has …

Chinese herbs nephropathy (CHN) and Balkan endemic nephropathy (BEN) are chronic
tubulointerstitial renal diseases associated with urothelial carcinoma. The clinical …

Traditional Chinese medicine (TCM) has used herbal remedies for more than 2,000 years.
The use of complimentary therapies has increased dramatically during the last years …

Background: Aristolochia species used in the practice of traditional herbal medicine contains
aristolochic acid (AA), an established human carcinogen contributing to urothelial …

This study was designed to establish the TP53 mutational spectrum of aristolochic acid (AA),
examined in the context of endemic (Balkan) nephropathy, an environmental disease …

Exposure to aristolochic acid (AA), a component of Aristolochia plants used in herbal
remedies, is associated with chronic kidney disease and urothelial carcinomas of the upper …