Migraine: disease characterisation, biomarkers, and precision medicine

M Ashina, GM Terwindt, MAM Al-Karagholi, I De Boer… - The Lancet, 2021 - thelancet.com
Migraine is a disabling neurological disorder, diagnosis of which is based on clinical criteria.
A shortcoming of these criteria is that they do not fully capture the heterogeneity of migraine …

Pathophysiology of migraine: a disorder of sensory processing

PJ Goadsby, PR Holland… - Physiological …, 2017 - journals.physiology.org
Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …

Neurogenic inflammation and its role in migraine

R Ramachandran - Seminars in immunopathology, 2018 - Springer
The etiology of migraine pain involves sensitized meningeal afferents that densely innervate
the dural vasculature. These afferents, with their cell bodies located in the trigeminal …

Debate: differences and similarities between tension-type headache and migraine

D Onan, S Younis, WD Wellsgatnik, F Farham… - The journal of headache …, 2023 - Springer
Tension-type headache (TTH) and migraine are two common primary headaches
distinguished by clinical characteristics according to the 3rd edition of the International …

Brain activations in the premonitory phase of nitroglycerin-triggered migraine attacks

FH Maniyar, T Sprenger, T Monteith, C Schankin… - Brain, 2014 - academic.oup.com
Our aim was identify brain areas involved in the premonitory phase of migraine using
functional neuroimaging. To this end, we performed positron emission tomography scans …

Migraine—current understanding and treatment

PJ Goadsby, RB Lipton, MD Ferrari - New England journal of …, 2002 - Mass Medical Soc
Migraine — Current Understanding and Treatment | New England Journal of Medicine Skip to
main content The New England Journal of Medicine homepage Advanced Search SEARCH …

Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus

Q Liu, Z Tang, L Surdenikova, S Kim, KN Patel, A Kim… - Cell, 2009 - cell.com
The cellular and molecular mechanisms mediating histamine-independent itch in primary
sensory neurons are largely unknown. Itch induced by chloroquine (CQ) is a common side …

CGRP may play a causative role in migraine

LH Lassen, PA Haderslev, VB Jacobsen… - …, 2002 - journals.sagepub.com
Calcitonin gene-related peptide (CGRP) has been detected in increased amounts in
external jugular venous blood during migraine attacks. However, it is unknown whether this …

Human models of migraine—short-term pain for long-term gain

M Ashina, JM Hansen, BO á Dunga… - Nature Reviews …, 2017 - nature.com
Migraine is a complex disorder characterized by recurrent episodes of headache, and is one
of the most prevalent and disabling neurological disorders. A key feature of migraine is that …

[HTML][HTML] The role of nitric oxide in brain disorders: Autism spectrum disorder and other psychiatric, neurological, and neurodegenerative disorders

MK Tripathi, M Kartawy, H Amal - Redox Biology, 2020 - Elsevier
Nitric oxide (NO) is a multifunctional signalling molecule and a neurotransmitter that plays
an important role in physiological and pathophysiological processes. In physiological …