As the gut microbiota exerts various effects on the intestinal milieu which influences distant
organs and pathways, it is considered to be a full-fledged endocrine organ. The microbiota …

Polycystic ovary syndrome (PCOS) is one of the most common systemic reproductive
endocrine diseases, which has a variety of effects on a woman's health. Because of the …

PCOS has a wide range of negative impacts on women's health and is one of the most
frequent reproductive systemic endocrine disorders. PCOS has complex characteristics and …

The female ovary contains a finite number of oocytes, and their release at ovulation
becomes sporadic and disordered with aging and with obesity, leading to loss of fertility …

Background: Diabetes reduces semen quality and increasingly occurs during reproductive
years. Diabetes medications, such as metformin, have glucose-independent effects on the …

Metformin (MF), a first-line drug to treat type 2 diabetes mellitus (T2DM), alone and in
combination with other drugs, restores the ovarian function in women with polycystic ovary …

Polycystic ovary syndrome (PCOS) is a common gynecological disease accompanied by a
variety of clinical features, including anovulation, hyperandrogenism, and ovarian …

In men with type 2 diabetes mellitus (T2DM), steroidogenesis and spermatogenesis are
impaired. Metformin and the agonists of luteinizing hormone/human chorionic gonadotropin …

Background: this study examined the metformin (MF) and/or chitosan stabilized selenium
nanoparticles (CH-SeNPs) efficacy to alleviate the male reproductive function impairment in …

Metformin, a biguanide drug, is the most commonly used first-line medication for type 2
diabetes mellites due to its outstanding glucose-lowering ability. After oral administration of …